Possible role of COVID-19 in the relapse of Klein-Levin Syndrome
Klein-Levin Syndrome (KLS) is an extremely rare neurological disorder which can manifest as recurring spells of sleepiness, cognitive disturbances and behavioral changes. We present a novel case of KLS relapse in the setting of Coronavirus disease-19 (COVID-19). A 36-year-old male who had a known hi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007121001076 |
| _version_ | 1818924227050340352 |
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| author | Adeel Nasrullah Anam Javed Obaid Ashraf Khalid Malik |
| author_facet | Adeel Nasrullah Anam Javed Obaid Ashraf Khalid Malik |
| author_sort | Adeel Nasrullah |
| collection | DOAJ |
| description | Klein-Levin Syndrome (KLS) is an extremely rare neurological disorder which can manifest as recurring spells of sleepiness, cognitive disturbances and behavioral changes. We present a novel case of KLS relapse in the setting of Coronavirus disease-19 (COVID-19). A 36-year-old male who had a known history of KLS since adolescence was admitted with sleepiness and behavioral disturbances. Brain imaging and autoimmune encephalitis work was unremarkable. The patient was diagnosed with a relapse of KLS secondary to COVID-19 based on symptomology and lack of any other precipitating factor. The patient required 8 days of hospitalization and was treated with benzodiazepines due to a history of robust response to lorazepam during a prior episode. The patient progressively improved and was discharged home on lorazepam taper. We report that similar to other neurotropic viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be the culprit in instigating KLS relapse. |
| first_indexed | 2024-12-20T02:21:58Z |
| format | Article |
| id | doaj.art-327570b0dc6c45c1b58aaf1885e85756 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-20T02:21:58Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-327570b0dc6c45c1b58aaf1885e857562022-12-21T19:56:48ZengElsevierRespiratory Medicine Case Reports2213-00712021-01-0133101445Possible role of COVID-19 in the relapse of Klein-Levin SyndromeAdeel Nasrullah0Anam Javed1Obaid Ashraf2Khalid Malik3Department of Medicine, Allegheny Health Network, Pittsburgh, PA, USA; Corresponding author. , 10 Allegheny Ctr, Apt 505, Pittsburgh, PA, 15212, USA.Department of Medicine, Allegheny Health Network, Pittsburgh, PA, USADepartement Pulmonology and Critical Care, Allegheny Health Network, Pittsburgh, PA, USADepartement Pulmonology and Critical Care, Allegheny Health Network, Pittsburgh, PA, USAKlein-Levin Syndrome (KLS) is an extremely rare neurological disorder which can manifest as recurring spells of sleepiness, cognitive disturbances and behavioral changes. We present a novel case of KLS relapse in the setting of Coronavirus disease-19 (COVID-19). A 36-year-old male who had a known history of KLS since adolescence was admitted with sleepiness and behavioral disturbances. Brain imaging and autoimmune encephalitis work was unremarkable. The patient was diagnosed with a relapse of KLS secondary to COVID-19 based on symptomology and lack of any other precipitating factor. The patient required 8 days of hospitalization and was treated with benzodiazepines due to a history of robust response to lorazepam during a prior episode. The patient progressively improved and was discharged home on lorazepam taper. We report that similar to other neurotropic viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be the culprit in instigating KLS relapse.http://www.sciencedirect.com/science/article/pii/S2213007121001076Klein-Levin syndromeHyperosmniaCOVID-19 |
| spellingShingle | Adeel Nasrullah Anam Javed Obaid Ashraf Khalid Malik Possible role of COVID-19 in the relapse of Klein-Levin Syndrome Respiratory Medicine Case Reports Klein-Levin syndrome Hyperosmnia COVID-19 |
| title | Possible role of COVID-19 in the relapse of Klein-Levin Syndrome |
| title_full | Possible role of COVID-19 in the relapse of Klein-Levin Syndrome |
| title_fullStr | Possible role of COVID-19 in the relapse of Klein-Levin Syndrome |
| title_full_unstemmed | Possible role of COVID-19 in the relapse of Klein-Levin Syndrome |
| title_short | Possible role of COVID-19 in the relapse of Klein-Levin Syndrome |
| title_sort | possible role of covid 19 in the relapse of klein levin syndrome |
| topic | Klein-Levin syndrome Hyperosmnia COVID-19 |
| url | http://www.sciencedirect.com/science/article/pii/S2213007121001076 |
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