Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants
The presence of conflicting stimuli adversely affects behavioral outcomes, which could either be at the level of stimulus (Flanker), response (Simon), or both (Multisource). Briefly, flanker interference involves conflicting stimuli requiring selective attention, Simon interference is caused by an i...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923005025 |
| _version_ | 1797683189108441088 |
|---|---|
| author | Yasra Arif Alex I. Wiesman Nicholas Christopher-Hayes Hannah J. Okelberry Hallie J. Johnson Madelyn P. Willett Tony W. Wilson |
| author_facet | Yasra Arif Alex I. Wiesman Nicholas Christopher-Hayes Hannah J. Okelberry Hallie J. Johnson Madelyn P. Willett Tony W. Wilson |
| author_sort | Yasra Arif |
| collection | DOAJ |
| description | The presence of conflicting stimuli adversely affects behavioral outcomes, which could either be at the level of stimulus (Flanker), response (Simon), or both (Multisource). Briefly, flanker interference involves conflicting stimuli requiring selective attention, Simon interference is caused by an incongruity between the spatial location of the task-relevant stimulus and prepotent motor mapping, and multisource is combination of both. Irrespective of the variant, interference resolution necessitates cognitive control to filter irrelevant information and allocate neural resources to task-related goals. Though previously studied in healthy young adults, the direct quantification of changes in oscillatory activity serving such cognitive control and associated inter-regional interactions in healthy aging are poorly understood. Herein, we used an adapted version of the multisource interference task and magnetoencephalography to investigate age-related alterations in the neural dynamics governing both divergent and convergent cognitive interference in 78 healthy participants (age range: 20-66 years). We identified weaker alpha connectivity between bilateral visual and right dorsolateral prefrontal cortices (DLPFC) and left dorsomedial prefrontal cortices (dmPFC), as well as weaker gamma connectivity between bilateral occipital regions and the right dmPFC during flanker interference with advancing age. Further, an age-related decrease in gamma power was observed in the left cerebellum and parietal region for Simon and differential interference effects (i.e., flanker-Simon), respectively. Moreover, the superadditivity model showed decreased gamma power in the right temporoparietal junction (TPJ) with increasing age. Overall, our findings suggest age-related declines in the engagement of top-down attentional control secondary to reduced alpha and gamma coupling between prefrontal and occipital cortices. |
| first_indexed | 2024-03-12T00:10:55Z |
| format | Article |
| id | doaj.art-3275981705354d92a099c4de6ce7227b |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-12T00:10:55Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-3275981705354d92a099c4de6ce7227b2023-09-16T05:28:57ZengElsevierNeuroImage1095-95722023-10-01280120351Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variantsYasra Arif0Alex I. Wiesman1Nicholas Christopher-Hayes2Hannah J. Okelberry3Hallie J. Johnson4Madelyn P. Willett5Tony W. Wilson6Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Correspondence to: Yasra Arif, Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, Phone: (402) 601-9086Montreal Neurological Institute, McGill University, Montreal, QC, CanadaInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USAInstitute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USAThe presence of conflicting stimuli adversely affects behavioral outcomes, which could either be at the level of stimulus (Flanker), response (Simon), or both (Multisource). Briefly, flanker interference involves conflicting stimuli requiring selective attention, Simon interference is caused by an incongruity between the spatial location of the task-relevant stimulus and prepotent motor mapping, and multisource is combination of both. Irrespective of the variant, interference resolution necessitates cognitive control to filter irrelevant information and allocate neural resources to task-related goals. Though previously studied in healthy young adults, the direct quantification of changes in oscillatory activity serving such cognitive control and associated inter-regional interactions in healthy aging are poorly understood. Herein, we used an adapted version of the multisource interference task and magnetoencephalography to investigate age-related alterations in the neural dynamics governing both divergent and convergent cognitive interference in 78 healthy participants (age range: 20-66 years). We identified weaker alpha connectivity between bilateral visual and right dorsolateral prefrontal cortices (DLPFC) and left dorsomedial prefrontal cortices (dmPFC), as well as weaker gamma connectivity between bilateral occipital regions and the right dmPFC during flanker interference with advancing age. Further, an age-related decrease in gamma power was observed in the left cerebellum and parietal region for Simon and differential interference effects (i.e., flanker-Simon), respectively. Moreover, the superadditivity model showed decreased gamma power in the right temporoparietal junction (TPJ) with increasing age. Overall, our findings suggest age-related declines in the engagement of top-down attentional control secondary to reduced alpha and gamma coupling between prefrontal and occipital cortices.http://www.sciencedirect.com/science/article/pii/S1053811923005025magnetoencephalographymultisource interference taskfunctional connectivityagingsuperadditivity |
| spellingShingle | Yasra Arif Alex I. Wiesman Nicholas Christopher-Hayes Hannah J. Okelberry Hallie J. Johnson Madelyn P. Willett Tony W. Wilson Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants NeuroImage magnetoencephalography multisource interference task functional connectivity aging superadditivity |
| title | Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants |
| title_full | Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants |
| title_fullStr | Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants |
| title_full_unstemmed | Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants |
| title_short | Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants |
| title_sort | altered age related alpha and gamma prefrontal occipital connectivity serving distinct cognitive interference variants |
| topic | magnetoencephalography multisource interference task functional connectivity aging superadditivity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923005025 |
| work_keys_str_mv | AT yasraarif alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants AT alexiwiesman alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants AT nicholaschristopherhayes alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants AT hannahjokelberry alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants AT halliejjohnson alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants AT madelynpwillett alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants AT tonywwilson alteredagerelatedalphaandgammaprefrontaloccipitalconnectivityservingdistinctcognitiveinterferencevariants |