Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report
Abstract Background Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare autoimmune encephalitis. The clinical symptoms of anti-DPPX encephalitis are often severe, manifested as diarrhea/weight loss, central nervous system hyperexcitability and cognitive dysfunction. Case presentat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02769-0 |
| _version_ | 1811328703569854464 |
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| author | Jing Lin Min Zhu Xiaocheng Mao Zeqing Jin Meihong Zhou Daojun Hong |
| author_facet | Jing Lin Min Zhu Xiaocheng Mao Zeqing Jin Meihong Zhou Daojun Hong |
| author_sort | Jing Lin |
| collection | DOAJ |
| description | Abstract Background Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare autoimmune encephalitis. The clinical symptoms of anti-DPPX encephalitis are often severe, manifested as diarrhea/weight loss, central nervous system hyperexcitability and cognitive dysfunction. Case presentation An 18-year-old boy was admitted for 1-week-long cerebellar symptoms including dizziness, unsteady gait and frequent vomiting. Magnetic resonance imaging (MRI) displayed no abnormal findings. However, autoimmune encephalitis panel revealed anti-DPPX antibody was positive in the serum. This patient completely recovered after immunoglobulin and corticoids therapy. In addition, repeat serum antibody test for DPPX was negative within one month. Conclusion In addition to the classic triad, anti-DPPX encephalitis may manifest as mild and rare symptoms due to lower antibody titers. Fast identification of rare symptoms can help to quickly diagnosis and effective treatment. |
| first_indexed | 2024-04-13T15:30:47Z |
| format | Article |
| id | doaj.art-3275cb413047422887a3b26936e96e8f |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-13T15:30:47Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-3275cb413047422887a3b26936e96e8f2022-12-22T02:41:23ZengBMCBMC Neurology1471-23772022-07-012211510.1186/s12883-022-02769-0Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case reportJing Lin0Min Zhu1Xiaocheng Mao2Zeqing Jin3Meihong Zhou4Daojun Hong5Department of Neurology, Dong’hu District, The First Affiliated Hospital of Nanchang UniversityDepartment of Neurology, Dong’hu District, The First Affiliated Hospital of Nanchang UniversityDepartment of Neurology, Dong’hu District, The First Affiliated Hospital of Nanchang UniversityDepartment of Neurology, Dong’hu District, The First Affiliated Hospital of Nanchang UniversityDepartment of Neurology, Dong’hu District, The First Affiliated Hospital of Nanchang UniversityDepartment of Neurology, Dong’hu District, The First Affiliated Hospital of Nanchang UniversityAbstract Background Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare autoimmune encephalitis. The clinical symptoms of anti-DPPX encephalitis are often severe, manifested as diarrhea/weight loss, central nervous system hyperexcitability and cognitive dysfunction. Case presentation An 18-year-old boy was admitted for 1-week-long cerebellar symptoms including dizziness, unsteady gait and frequent vomiting. Magnetic resonance imaging (MRI) displayed no abnormal findings. However, autoimmune encephalitis panel revealed anti-DPPX antibody was positive in the serum. This patient completely recovered after immunoglobulin and corticoids therapy. In addition, repeat serum antibody test for DPPX was negative within one month. Conclusion In addition to the classic triad, anti-DPPX encephalitis may manifest as mild and rare symptoms due to lower antibody titers. Fast identification of rare symptoms can help to quickly diagnosis and effective treatment.https://doi.org/10.1186/s12883-022-02769-0Autoimmune encephalitisDipeptidyl-peptidase-like protein 6Cerebellar ataxiaAntibodyCase report |
| spellingShingle | Jing Lin Min Zhu Xiaocheng Mao Zeqing Jin Meihong Zhou Daojun Hong Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report BMC Neurology Autoimmune encephalitis Dipeptidyl-peptidase-like protein 6 Cerebellar ataxia Antibody Case report |
| title | Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report |
| title_full | Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report |
| title_fullStr | Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report |
| title_full_unstemmed | Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report |
| title_short | Anti-dipeptidyl-peptidase-like protein 6 encephalitis with pure cerebellar ataxia: a case report |
| title_sort | anti dipeptidyl peptidase like protein 6 encephalitis with pure cerebellar ataxia a case report |
| topic | Autoimmune encephalitis Dipeptidyl-peptidase-like protein 6 Cerebellar ataxia Antibody Case report |
| url | https://doi.org/10.1186/s12883-022-02769-0 |
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