Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study
Abstract Background Endocrine drugs may affect lipid metabolism in breast cancer (BC) patients. This study explores lipid changes in early-stage BC patients taking different endocrine drugs. Methods The changing trend of blood lipid during endocrine therapy in 2756 BC patients from January 2013 to D...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-024-02002-6 |
| _version_ | 1827381988161486848 |
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| author | Yuechong Li Zixi Deng Yingjiao Wang Songjie Shen |
| author_facet | Yuechong Li Zixi Deng Yingjiao Wang Songjie Shen |
| author_sort | Yuechong Li |
| collection | DOAJ |
| description | Abstract Background Endocrine drugs may affect lipid metabolism in breast cancer (BC) patients. This study explores lipid changes in early-stage BC patients taking different endocrine drugs. Methods The changing trend of blood lipid during endocrine therapy in 2756 BC patients from January 2013 to December 2021 was retrospectively analyzed. The changes in four lipid parameters were assessed by the Generalized Linear Mixed Model, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C). These parameters were quantified at baseline and at 6, 12, 18, 24, 36, 48, 60, and 72 months after endocrine therapy initiation. Furthermore, a subgroup analysis according to menopausal status or medication types was conducted. Results A total of 1201 patients taking aromatase inhibitors (AIs), including anastrozole (ANA), letrozole (LET), or exemestane (EXE), and 1555 patients taking toremifene (TOR) were enrolled. TC and TG levels showed a significantly elevated trend during 5 years of treatment (P < 0.05). HDL-C levels increased from baseline in the TOR group (P < 0.05). Compared with the postmenopausal AI group, the increasing trends of TC, TG, and LDL-C in the premenopausal AI group were more evident with the extension of time (β = 0.105, 0.027, 0.086, respectively). Within 3 years, TC, TG, and LDL-C levels in the ANA and LET groups were significantly higher than baseline (P < 0.05). Moreover, the levels of TG in the EXE group were significantly lower than that in the ANA or LET group (P < 0.05), but this significant difference disappeared after 3 years. Conclusions AIs significantly influenced lipid profiles more than TOR. AIs had a greater effect on blood lipids in premenopausal patients. Steroidal AIs (EXE) may affect lipid levels less than nonsteroidal AIs (ANA and LET). |
| first_indexed | 2024-03-08T14:12:58Z |
| format | Article |
| id | doaj.art-327650bfba8e49f2a9bd5528cbf6478e |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-08T14:12:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-327650bfba8e49f2a9bd5528cbf6478e2024-01-14T12:34:46ZengBMCLipids in Health and Disease1476-511X2024-01-0123111110.1186/s12944-024-02002-6Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world studyYuechong Li0Zixi Deng1Yingjiao Wang2Songjie Shen3Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesAbstract Background Endocrine drugs may affect lipid metabolism in breast cancer (BC) patients. This study explores lipid changes in early-stage BC patients taking different endocrine drugs. Methods The changing trend of blood lipid during endocrine therapy in 2756 BC patients from January 2013 to December 2021 was retrospectively analyzed. The changes in four lipid parameters were assessed by the Generalized Linear Mixed Model, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C). These parameters were quantified at baseline and at 6, 12, 18, 24, 36, 48, 60, and 72 months after endocrine therapy initiation. Furthermore, a subgroup analysis according to menopausal status or medication types was conducted. Results A total of 1201 patients taking aromatase inhibitors (AIs), including anastrozole (ANA), letrozole (LET), or exemestane (EXE), and 1555 patients taking toremifene (TOR) were enrolled. TC and TG levels showed a significantly elevated trend during 5 years of treatment (P < 0.05). HDL-C levels increased from baseline in the TOR group (P < 0.05). Compared with the postmenopausal AI group, the increasing trends of TC, TG, and LDL-C in the premenopausal AI group were more evident with the extension of time (β = 0.105, 0.027, 0.086, respectively). Within 3 years, TC, TG, and LDL-C levels in the ANA and LET groups were significantly higher than baseline (P < 0.05). Moreover, the levels of TG in the EXE group were significantly lower than that in the ANA or LET group (P < 0.05), but this significant difference disappeared after 3 years. Conclusions AIs significantly influenced lipid profiles more than TOR. AIs had a greater effect on blood lipids in premenopausal patients. Steroidal AIs (EXE) may affect lipid levels less than nonsteroidal AIs (ANA and LET).https://doi.org/10.1186/s12944-024-02002-6Lipid profileBreast cancerEndocrine therapyToremifeneAromatase inhibitors |
| spellingShingle | Yuechong Li Zixi Deng Yingjiao Wang Songjie Shen Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study Lipids in Health and Disease Lipid profile Breast cancer Endocrine therapy Toremifene Aromatase inhibitors |
| title | Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study |
| title_full | Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study |
| title_fullStr | Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study |
| title_full_unstemmed | Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study |
| title_short | Lipid changes during endocrine therapy in early-stage breast cancer patients: A real-world study |
| title_sort | lipid changes during endocrine therapy in early stage breast cancer patients a real world study |
| topic | Lipid profile Breast cancer Endocrine therapy Toremifene Aromatase inhibitors |
| url | https://doi.org/10.1186/s12944-024-02002-6 |
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