Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis

Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis

The correlation between ubiquitin-editing enzyme A20 and E3 ubiquitin ligase ring finger protein (RNF) 168 has been reported to be critical for repair of DNA damage. This study aimed to evaluate the potential role of this regulatory interaction in the pathogenesis of lupus nephritis (LN). The expres...

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Bibliographic Details
Main Authors: Luxi Zou, Ling Sun, Ruixue Hua, Yu Wu, Linlin Sun, Ting Chen
Format: Article
Language:English
Published: Karger Publishers 2023-03-01
Series:Journal of Innate Immunity
Subjects:
lupus nephritis
a20
rnf168
nf-κb
autophagy
podocytes
dna damage
Online Access:https://www.karger.com/Article/FullText/527624

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