Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis
Background: To compare conventional smears (CSs) and liquid-based preparations (LBPs) for diagnosing thyroid malignant or suspicious lesions. Methods: Studies in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane database published up to December 2023. We reviewed 17 studies, including 15,861...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/4/751 |
| _version_ | 1797298675330842624 |
|---|---|
| author | Yun Jin Kang Hyeon Woo Lee Gulnaz Stybayeva Se Hwan Hwang |
| author_facet | Yun Jin Kang Hyeon Woo Lee Gulnaz Stybayeva Se Hwan Hwang |
| author_sort | Yun Jin Kang |
| collection | DOAJ |
| description | Background: To compare conventional smears (CSs) and liquid-based preparations (LBPs) for diagnosing thyroid malignant or suspicious lesions. Methods: Studies in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane database published up to December 2023. We reviewed 17 studies, including 15,861 samples. Results: The diagnostic odds ratio (DOR) for CS was 23.6674. The area under the summary receiver operating characteristic curve (AUC) was 0.879, with sensitivity, specificity, negative predictive value, and positive predictive value of 0.8266, 0.8668, 0.8969, and 0.7841, respectively. The rate of inadequate specimens was 0.1280. For LBP, the DOR was 25.3587, with an AUC of 0.865. The sensitivity, specificity, negative predictive value, and positive predictive value were 0.8190, 0.8833, 0.8515, and 0.8562. The rate of inadequate specimens was 0.1729. For CS plus LBP, the AUC was 0.813, with a lower DOR of 9.4557 compared to individual methods. Diagnostic accuracy did not significantly differ among CS, LBP, and CS plus LBP. Subgroup analysis was used to compare ThinPrep and SurePath. The DORs were 29.1494 and 19.7734. SurePath had a significantly higher AUC. Conclusions: There was no significant difference in diagnostic accuracy or proportion of inadequate smears between CS and LBP. SurePath demonstrated higher diagnostic accuracy than ThinPrep. Recommendations for fine-needle aspiration cytology should consider cost, feasibility, and accuracy. |
| first_indexed | 2024-03-07T22:38:27Z |
| format | Article |
| id | doaj.art-3276bad2c3044a4aa95414ad3e93ed12 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-07T22:38:27Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3276bad2c3044a4aa95414ad3e93ed122024-02-23T15:10:47ZengMDPI AGCancers2072-66942024-02-0116475110.3390/cancers16040751Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-AnalysisYun Jin Kang0Hyeon Woo Lee1Gulnaz Stybayeva2Se Hwan Hwang3Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan 14584, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan 14584, Republic of KoreaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USADepartment of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaBackground: To compare conventional smears (CSs) and liquid-based preparations (LBPs) for diagnosing thyroid malignant or suspicious lesions. Methods: Studies in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane database published up to December 2023. We reviewed 17 studies, including 15,861 samples. Results: The diagnostic odds ratio (DOR) for CS was 23.6674. The area under the summary receiver operating characteristic curve (AUC) was 0.879, with sensitivity, specificity, negative predictive value, and positive predictive value of 0.8266, 0.8668, 0.8969, and 0.7841, respectively. The rate of inadequate specimens was 0.1280. For LBP, the DOR was 25.3587, with an AUC of 0.865. The sensitivity, specificity, negative predictive value, and positive predictive value were 0.8190, 0.8833, 0.8515, and 0.8562. The rate of inadequate specimens was 0.1729. For CS plus LBP, the AUC was 0.813, with a lower DOR of 9.4557 compared to individual methods. Diagnostic accuracy did not significantly differ among CS, LBP, and CS plus LBP. Subgroup analysis was used to compare ThinPrep and SurePath. The DORs were 29.1494 and 19.7734. SurePath had a significantly higher AUC. Conclusions: There was no significant difference in diagnostic accuracy or proportion of inadequate smears between CS and LBP. SurePath demonstrated higher diagnostic accuracy than ThinPrep. Recommendations for fine-needle aspiration cytology should consider cost, feasibility, and accuracy.https://www.mdpi.com/2072-6694/16/4/751thyroid glandfine-needle aspiration biopsycytologyconventional smearsliquid-based preparationmeta-analysis |
| spellingShingle | Yun Jin Kang Hyeon Woo Lee Gulnaz Stybayeva Se Hwan Hwang Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis Cancers thyroid gland fine-needle aspiration biopsy cytology conventional smears liquid-based preparation meta-analysis |
| title | Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis |
| title_full | Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis |
| title_fullStr | Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis |
| title_short | Comparison of Liquid-Based Preparations with Conventional Smears in Thyroid Fine-Needle Aspirates: A Systematic Review and Meta-Analysis |
| title_sort | comparison of liquid based preparations with conventional smears in thyroid fine needle aspirates a systematic review and meta analysis |
| topic | thyroid gland fine-needle aspiration biopsy cytology conventional smears liquid-based preparation meta-analysis |
| url | https://www.mdpi.com/2072-6694/16/4/751 |
| work_keys_str_mv | AT yunjinkang comparisonofliquidbasedpreparationswithconventionalsmearsinthyroidfineneedleaspiratesasystematicreviewandmetaanalysis AT hyeonwoolee comparisonofliquidbasedpreparationswithconventionalsmearsinthyroidfineneedleaspiratesasystematicreviewandmetaanalysis AT gulnazstybayeva comparisonofliquidbasedpreparationswithconventionalsmearsinthyroidfineneedleaspiratesasystematicreviewandmetaanalysis AT sehwanhwang comparisonofliquidbasedpreparationswithconventionalsmearsinthyroidfineneedleaspiratesasystematicreviewandmetaanalysis |