Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder
ObjectivesAttention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide. Although synaptosomal-associated protein 25 (SNAP-25) is a possible gene hypothesized to be associated with working memory deficits...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1219189/full |
| _version_ | 1797745883403517952 |
|---|---|
| author | Wenxian Huang Wenxian Huang Ahmed Ameen Fateh Yilin Zhao Yilin Zhao Hongwu Zeng Binrang Yang Diangang Fang Linlin Zhang Xianlei Meng Muhammad Hassan Feiqiu Wen |
| author_facet | Wenxian Huang Wenxian Huang Ahmed Ameen Fateh Yilin Zhao Yilin Zhao Hongwu Zeng Binrang Yang Diangang Fang Linlin Zhang Xianlei Meng Muhammad Hassan Feiqiu Wen |
| author_sort | Wenxian Huang |
| collection | DOAJ |
| description | ObjectivesAttention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide. Although synaptosomal-associated protein 25 (SNAP-25) is a possible gene hypothesized to be associated with working memory deficits in ADHD, little is known about its specific impact on the hippocampus. The goal of the current study was to determine how variations in ADHD’s SNAP-25 Mnll polymorphism (rs3746544) affect hippocampal functional connectivity (FC).MethodsA total of 88 boys between the ages of 7 and 10 years were recruited for the study, including 60 patients with ADHD and 28 healthy controls (HCs). Data from resting-state functional magnetic resonance imaging (rs-fMRI) and clinical information were acquired and assessed. Two single nucleotide polymorphisms (SNP) in the SNAP-25 gene were genotyped, according to which the study’s findings separated ADHD patients into two groups: TT homozygotes (TT = 35) and G-allele carriers (TG = 25).ResultsBased on the rs-fMRI data, the FC of the right hippocampus and left frontal gyrus was evaluated using group-based comparisons. The corresponding sensitivities and specificities were assessed. Following comparisons between the patient groups, different hippocampal FCs were identified. When compared to TT patients, children with TG had a lower FC between the right precuneus and the right hippocampus, and a higher FC between the right hippocampus and the left middle frontal gyrus.ConclusionThe fundamental neurological pathways connecting the SNAP-25 Mnll polymorphism with ADHD via the FC of the hippocampus were newly revealed in this study. As a result, the hippocampal FC may further serve as an imaging biomarker for ADHD. |
| first_indexed | 2024-03-12T15:29:20Z |
| format | Article |
| id | doaj.art-3278cc1887c94d439e9d7455fa77c8ac |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-03-12T15:29:20Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-3278cc1887c94d439e9d7455fa77c8ac2023-08-10T08:47:40ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-08-011710.3389/fnhum.2023.12191891219189Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorderWenxian Huang0Wenxian Huang1Ahmed Ameen Fateh2Yilin Zhao3Yilin Zhao4Hongwu Zeng5Binrang Yang6Diangang Fang7Linlin Zhang8Xianlei Meng9Muhammad Hassan10Feiqiu Wen11Department of Pediatric China Medical University, Shenyang, ChinaHealthy Care Center, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Pediatric China Medical University, Shenyang, ChinaDepartment of Radiology, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children’s Hospital, Shenzhen, ChinaHealthy Care Center, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children’s Hospital, Shenzhen, ChinaHealthy Care Center, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Radiology, Shenzhen Children’s Hospital, Shenzhen, ChinaDepartment of Pediatrics, Shenzhen Children’s Hospital, Shenzhen, ChinaObjectivesAttention-deficit/hyperactivity disorder (ADHD) is one of the most widespread and highly heritable neurodevelopmental disorders affecting children worldwide. Although synaptosomal-associated protein 25 (SNAP-25) is a possible gene hypothesized to be associated with working memory deficits in ADHD, little is known about its specific impact on the hippocampus. The goal of the current study was to determine how variations in ADHD’s SNAP-25 Mnll polymorphism (rs3746544) affect hippocampal functional connectivity (FC).MethodsA total of 88 boys between the ages of 7 and 10 years were recruited for the study, including 60 patients with ADHD and 28 healthy controls (HCs). Data from resting-state functional magnetic resonance imaging (rs-fMRI) and clinical information were acquired and assessed. Two single nucleotide polymorphisms (SNP) in the SNAP-25 gene were genotyped, according to which the study’s findings separated ADHD patients into two groups: TT homozygotes (TT = 35) and G-allele carriers (TG = 25).ResultsBased on the rs-fMRI data, the FC of the right hippocampus and left frontal gyrus was evaluated using group-based comparisons. The corresponding sensitivities and specificities were assessed. Following comparisons between the patient groups, different hippocampal FCs were identified. When compared to TT patients, children with TG had a lower FC between the right precuneus and the right hippocampus, and a higher FC between the right hippocampus and the left middle frontal gyrus.ConclusionThe fundamental neurological pathways connecting the SNAP-25 Mnll polymorphism with ADHD via the FC of the hippocampus were newly revealed in this study. As a result, the hippocampal FC may further serve as an imaging biomarker for ADHD.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1219189/fullADHDSNAP-25functional connectivityhippocampusfMRI |
| spellingShingle | Wenxian Huang Wenxian Huang Ahmed Ameen Fateh Yilin Zhao Yilin Zhao Hongwu Zeng Binrang Yang Diangang Fang Linlin Zhang Xianlei Meng Muhammad Hassan Feiqiu Wen Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder Frontiers in Human Neuroscience ADHD SNAP-25 functional connectivity hippocampus fMRI |
| title | Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder |
| title_full | Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder |
| title_fullStr | Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder |
| title_full_unstemmed | Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder |
| title_short | Effects of the SNAP-25 Mnll variant on hippocampal functional connectivity in children with attention deficit/hyperactivity disorder |
| title_sort | effects of the snap 25 mnll variant on hippocampal functional connectivity in children with attention deficit hyperactivity disorder |
| topic | ADHD SNAP-25 functional connectivity hippocampus fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1219189/full |
| work_keys_str_mv | AT wenxianhuang effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT wenxianhuang effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT ahmedameenfateh effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT yilinzhao effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT yilinzhao effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT hongwuzeng effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT binrangyang effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT diangangfang effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT linlinzhang effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT xianleimeng effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT muhammadhassan effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder AT feiqiuwen effectsofthesnap25mnllvariantonhippocampalfunctionalconnectivityinchildrenwithattentiondeficithyperactivitydisorder |