Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia
Objective: Interaction between genetic and environmental factors is considered as major factors in Schizophrenia (SCZ). It has been shown that dopaminergic and noradrenergic neurotransmission dysfunction play an essential role in the SCZ pathogenesis. This study aimed to find the impact of function...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2016-12-01
|
| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/523 |
| _version_ | 1811279090723848192 |
|---|---|
| author | Mansour shakiba Mohammad Hashemi Sara Shahrabadi Maryam Rezaei Mohsen Taheri |
| author_facet | Mansour shakiba Mohammad Hashemi Sara Shahrabadi Maryam Rezaei Mohsen Taheri |
| author_sort | Mansour shakiba |
| collection | DOAJ |
| description | Objective: Interaction between genetic and environmental factors is considered as major factors in Schizophrenia (SCZ). It has been shown that dopaminergic and noradrenergic neurotransmission dysfunction play an essential role in the SCZ pathogenesis.
This study aimed to find the impact of functional 19-bp insertion/deletion (ins/del) polymorphism in dopamine beta-hydroxylase (DBH) gene on SCZ risk in a sample of Iranian population.
Method: This case-control study was conducted on 109 SCZ patients and 116 matched healthy subjects. Genomic DNA samples were extracted from peripheral blood cells using salting out method. Genotyping of 19-bp ins/del DBH polymorphism was done using Polymerase Chain Reaction (PCR) method.
Results: Neither the overall chi-square comparison of cases and controls ( |
| first_indexed | 2024-04-13T00:48:22Z |
| format | Article |
| id | doaj.art-327975df721a4d8482596e44c614ecd0 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-04-13T00:48:22Z |
| publishDate | 2016-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-327975df721a4d8482596e44c614ecd02022-12-22T03:09:56ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152016-12-01114567Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of SchizophreniaMansour shakiba0Mohammad Hashemi1Sara Shahrabadi2Maryam Rezaei3Mohsen Taheri4Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. AND Department of Psychiatry, Zahedan University of Medical Sciences, Zahedan, Iran.. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. AND Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Psychiatry, Zahedan University of Medical Sciences, Zahedan, Iran.Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.Genetics of Non-Communicable Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.Objective: Interaction between genetic and environmental factors is considered as major factors in Schizophrenia (SCZ). It has been shown that dopaminergic and noradrenergic neurotransmission dysfunction play an essential role in the SCZ pathogenesis. This study aimed to find the impact of functional 19-bp insertion/deletion (ins/del) polymorphism in dopamine beta-hydroxylase (DBH) gene on SCZ risk in a sample of Iranian population. Method: This case-control study was conducted on 109 SCZ patients and 116 matched healthy subjects. Genomic DNA samples were extracted from peripheral blood cells using salting out method. Genotyping of 19-bp ins/del DBH polymorphism was done using Polymerase Chain Reaction (PCR) method. Results: Neither the overall chi-square comparison of cases and controls (https://ijps.tums.ac.ir/index.php/ijps/article/view/523DeletionDopamine Beta-HydroxylaseInsertionPolymorphismSchizophrenia |
| spellingShingle | Mansour shakiba Mohammad Hashemi Sara Shahrabadi Maryam Rezaei Mohsen Taheri Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia Iranian Journal of Psychiatry Deletion Dopamine Beta-Hydroxylase Insertion Polymorphism Schizophrenia |
| title | Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia |
| title_full | Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia |
| title_fullStr | Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia |
| title_full_unstemmed | Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia |
| title_short | Lack of Association between Dopamine Beta-Hydroxylase (DBH) 19-bp Insertion/Deletion Polymorphism and Risk of Schizophrenia |
| title_sort | lack of association between dopamine beta hydroxylase dbh 19 bp insertion deletion polymorphism and risk of schizophrenia |
| topic | Deletion Dopamine Beta-Hydroxylase Insertion Polymorphism Schizophrenia |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/523 |
| work_keys_str_mv | AT mansourshakiba lackofassociationbetweendopaminebetahydroxylasedbh19bpinsertiondeletionpolymorphismandriskofschizophrenia AT mohammadhashemi lackofassociationbetweendopaminebetahydroxylasedbh19bpinsertiondeletionpolymorphismandriskofschizophrenia AT sarashahrabadi lackofassociationbetweendopaminebetahydroxylasedbh19bpinsertiondeletionpolymorphismandriskofschizophrenia AT maryamrezaei lackofassociationbetweendopaminebetahydroxylasedbh19bpinsertiondeletionpolymorphismandriskofschizophrenia AT mohsentaheri lackofassociationbetweendopaminebetahydroxylasedbh19bpinsertiondeletionpolymorphismandriskofschizophrenia |