Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise
Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21−adiponectin axis i...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/3/221 |
| _version_ | 1797762641680138240 |
|---|---|
| author | Shuen Yee Lee Stephen F. Burns Kenneth K.C. Ng David J. Stensel Liang Zhong Frankie H.Y. Tan Kar Ling Chia Kai Deng Fam Margaret M.C. Yap Kwee Poo Yeo Eric P.H. Yap Chin Leong Lim |
| author_facet | Shuen Yee Lee Stephen F. Burns Kenneth K.C. Ng David J. Stensel Liang Zhong Frankie H.Y. Tan Kar Ling Chia Kai Deng Fam Margaret M.C. Yap Kwee Poo Yeo Eric P.H. Yap Chin Leong Lim |
| author_sort | Shuen Yee Lee |
| collection | DOAJ |
| description | Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21−adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18−36 years old, <i>n</i> = 20 each) and older sedentary or active (45−80 years old, <i>n</i> = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both <i>p</i> < 0.001) in older than younger adults, despite no difference in FGF21 concentration (<i>p =</i> 0.097) between age groups. PWV (<i>p</i> = 0.09) and oxLDL concentration (<i>p =</i> 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (<i>p</i> = 0.011). Adiponectin concentration did not differ by age (<i>p</i> = 0.642) or exercise habits (<i>p</i> = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults. |
| first_indexed | 2024-03-12T19:30:22Z |
| format | Article |
| id | doaj.art-327990e473124637ac9cd9d3a46b2943 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:30:22Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-327990e473124637ac9cd9d3a46b29432023-08-02T04:34:02ZengMDPI AGAntioxidants2076-39212020-03-019322110.3390/antiox9030221antiox9030221Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual ExerciseShuen Yee Lee0Stephen F. Burns1Kenneth K.C. Ng2David J. Stensel3Liang Zhong4Frankie H.Y. Tan5Kar Ling Chia6Kai Deng Fam7Margaret M.C. Yap8Kwee Poo Yeo9Eric P.H. Yap10Chin Leong Lim11Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporePhysical Education and Sports Science Academic Group, National Institute of Education, Nanyang Technological University, Singapore 637616, SingaporeNovena Heart Centre, Singapore 329563, SingaporeNational Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire LE11 3TU, UKNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, SingaporeSport Science & Medicine Centre, Singapore Sport Institute, Sport Singapore, Singapore 397630, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeSchool of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeFibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21−adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18−36 years old, <i>n</i> = 20 each) and older sedentary or active (45−80 years old, <i>n</i> = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both <i>p</i> < 0.001) in older than younger adults, despite no difference in FGF21 concentration (<i>p =</i> 0.097) between age groups. PWV (<i>p</i> = 0.09) and oxLDL concentration (<i>p =</i> 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (<i>p</i> = 0.011). Adiponectin concentration did not differ by age (<i>p</i> = 0.642) or exercise habits (<i>p</i> = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults.https://www.mdpi.com/2076-3921/9/3/221exerciseageingoxldlarterial stiffness |
| spellingShingle | Shuen Yee Lee Stephen F. Burns Kenneth K.C. Ng David J. Stensel Liang Zhong Frankie H.Y. Tan Kar Ling Chia Kai Deng Fam Margaret M.C. Yap Kwee Poo Yeo Eric P.H. Yap Chin Leong Lim Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise Antioxidants exercise ageing oxldl arterial stiffness |
| title | Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise |
| title_full | Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise |
| title_fullStr | Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise |
| title_full_unstemmed | Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise |
| title_short | Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise |
| title_sort | pulse wave velocity is associated with increased plasma oxldl in ageing but not with fgf21 and habitual exercise |
| topic | exercise ageing oxldl arterial stiffness |
| url | https://www.mdpi.com/2076-3921/9/3/221 |
| work_keys_str_mv | AT shuenyeelee pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT stephenfburns pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT kennethkcng pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT davidjstensel pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT liangzhong pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT frankiehytan pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT karlingchia pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT kaidengfam pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT margaretmcyap pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT kweepooyeo pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT ericphyap pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise AT chinleonglim pulsewavevelocityisassociatedwithincreasedplasmaoxldlinageingbutnotwithfgf21andhabitualexercise |