Cardiac Sarcomere Signaling in Health and Disease
The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs. This review focuses on the many signaling components and mechanisms of r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/24/16223 |
| _version_ | 1797457186913255424 |
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| author | Ashley A. Martin Brian R. Thompson Dongwoo Hahn Addeli Bez Batti Angulski Nora Hosny Houda Cohen Joseph M. Metzger |
| author_facet | Ashley A. Martin Brian R. Thompson Dongwoo Hahn Addeli Bez Batti Angulski Nora Hosny Houda Cohen Joseph M. Metzger |
| author_sort | Ashley A. Martin |
| collection | DOAJ |
| description | The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs. This review focuses on the many signaling components and mechanisms of regulation that impact cardiac sarcomere function. We highlight the roles of the thick and thin filament, both as necessary structural and regulatory building blocks of the sarcomere as well as targets of functionally impactful modifications. Currently, a new focus emerging in the field is inter-myofilament signaling, and we discuss here the important mediators of this mechanism, including myosin-binding protein C and titin. As the understanding of sarcomere signaling advances, so do the methods with which it is studied. This is reviewed here through discussion of recent live muscle systems in which the sarcomere can be studied under intact, physiologically relevant conditions. |
| first_indexed | 2024-03-09T16:18:35Z |
| format | Article |
| id | doaj.art-3279a92b15234957bda4169c072d0d48 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:18:35Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3279a92b15234957bda4169c072d0d482023-11-24T15:35:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241622310.3390/ijms232416223Cardiac Sarcomere Signaling in Health and DiseaseAshley A. Martin0Brian R. Thompson1Dongwoo Hahn2Addeli Bez Batti Angulski3Nora Hosny4Houda Cohen5Joseph M. Metzger6Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USADepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USADepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USADepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USADepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USADepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USADepartment of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USAThe cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point upon which cardiac muscle contraction occurs. This review focuses on the many signaling components and mechanisms of regulation that impact cardiac sarcomere function. We highlight the roles of the thick and thin filament, both as necessary structural and regulatory building blocks of the sarcomere as well as targets of functionally impactful modifications. Currently, a new focus emerging in the field is inter-myofilament signaling, and we discuss here the important mediators of this mechanism, including myosin-binding protein C and titin. As the understanding of sarcomere signaling advances, so do the methods with which it is studied. This is reviewed here through discussion of recent live muscle systems in which the sarcomere can be studied under intact, physiologically relevant conditions.https://www.mdpi.com/1422-0067/23/24/16223cardiac muscletroponinmyosinmyosin-binding protein ctitinheart disease |
| spellingShingle | Ashley A. Martin Brian R. Thompson Dongwoo Hahn Addeli Bez Batti Angulski Nora Hosny Houda Cohen Joseph M. Metzger Cardiac Sarcomere Signaling in Health and Disease International Journal of Molecular Sciences cardiac muscle troponin myosin myosin-binding protein c titin heart disease |
| title | Cardiac Sarcomere Signaling in Health and Disease |
| title_full | Cardiac Sarcomere Signaling in Health and Disease |
| title_fullStr | Cardiac Sarcomere Signaling in Health and Disease |
| title_full_unstemmed | Cardiac Sarcomere Signaling in Health and Disease |
| title_short | Cardiac Sarcomere Signaling in Health and Disease |
| title_sort | cardiac sarcomere signaling in health and disease |
| topic | cardiac muscle troponin myosin myosin-binding protein c titin heart disease |
| url | https://www.mdpi.com/1422-0067/23/24/16223 |
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