Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer

<p>Abstract</p> <p>Background</p> <p>To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value.</p> <p>Methods</p> <p>Immunohistochemical staining for GOLPH3 was performed on tissue mic...

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Main Authors: Hua Xing, Yu Lina, Pan Wenhai, Huang Xiaoxiao, Liao Zexiao, Xian Qi, Fang Li, Shen Hong
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Diagnostic Pathology
Subjects:
Online Access:http://www.diagnosticpathology.org/content/7/1/127
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author Hua Xing
Yu Lina
Pan Wenhai
Huang Xiaoxiao
Liao Zexiao
Xian Qi
Fang Li
Shen Hong
author_facet Hua Xing
Yu Lina
Pan Wenhai
Huang Xiaoxiao
Liao Zexiao
Xian Qi
Fang Li
Shen Hong
author_sort Hua Xing
collection DOAJ
description <p>Abstract</p> <p>Background</p> <p>To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value.</p> <p>Methods</p> <p>Immunohistochemical staining for GOLPH3 was performed on tissue microarrays of 342 prostate patients. The correlation between GOLPH3 expression with its clinicopathologic factors was also analyzed in order to determine its prognostic significance.</p> <p>Results</p> <p>GOLPH3 expression of normal prostate tissues, benign prostate hyperplasia, high-grade prostatic intraepithelial neoplasia, and hormone-dependent prostate cancer (HDPC) did not show any statistically significant difference. In contrast, statistically significant difference was reported in moderate/intense GOLPH3 expression in cases diagnosed with HDPC and castration resistant prostate cancer (CRPC) (<it>P</it> < 0.0005). Moderate /intense expression of GOLPH3 was associated with androgen independence (<it>P</it> = 0.012), higher Gleason score (<it>P</it> = 0.017), bone metastasis (<it>P</it> = 0.024), higher baseline prostate-specific antigen (PSA) (<it>P</it> = 0.038), and higher PSA nadir (<it>P</it> = 0.032). A significantly negative correlation was found between moderate/intense GOLPH3 expression and disease-free survival (DFS) (HR = 0.28, <it>P</it> = 0.012) and overall survival (OS) (HR = 0.42, <it>P</it> = 0.027). Univariated analysis indicated that moderate/intense GOLPH3 expression created a significantly prognostic impact in patients with CRPC. On the other hand, multivariate analysis indicated that GOLPH3 was a significantly independent prognostic factor of DFS (<it>P</it> = 0.027) in all prostate cancer patients.</p> <p>Conclusions</p> <p>In this study, it was discovered that the overexpression of GOLPH3 is associated with the transition of prostate cancer from hormone sensitive phase to hormone refractory phase. GOLPH3 might be an important prognostic factor of DFS and OS in patients with prostate cancer. In totality, GOLPH3 could be used as a novel candidate in devising a more effective therapeutic strategy to tackle CRPC.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1452541171722856</url>.</p>
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spelling doaj.art-327b36017c1c416cae7805528ca67baa2022-12-21T20:55:17ZengBMCDiagnostic Pathology1746-15962012-09-017112710.1186/1746-1596-7-127Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancerHua XingYu LinaPan WenhaiHuang XiaoxiaoLiao ZexiaoXian QiFang LiShen Hong<p>Abstract</p> <p>Background</p> <p>To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value.</p> <p>Methods</p> <p>Immunohistochemical staining for GOLPH3 was performed on tissue microarrays of 342 prostate patients. The correlation between GOLPH3 expression with its clinicopathologic factors was also analyzed in order to determine its prognostic significance.</p> <p>Results</p> <p>GOLPH3 expression of normal prostate tissues, benign prostate hyperplasia, high-grade prostatic intraepithelial neoplasia, and hormone-dependent prostate cancer (HDPC) did not show any statistically significant difference. In contrast, statistically significant difference was reported in moderate/intense GOLPH3 expression in cases diagnosed with HDPC and castration resistant prostate cancer (CRPC) (<it>P</it> < 0.0005). Moderate /intense expression of GOLPH3 was associated with androgen independence (<it>P</it> = 0.012), higher Gleason score (<it>P</it> = 0.017), bone metastasis (<it>P</it> = 0.024), higher baseline prostate-specific antigen (PSA) (<it>P</it> = 0.038), and higher PSA nadir (<it>P</it> = 0.032). A significantly negative correlation was found between moderate/intense GOLPH3 expression and disease-free survival (DFS) (HR = 0.28, <it>P</it> = 0.012) and overall survival (OS) (HR = 0.42, <it>P</it> = 0.027). Univariated analysis indicated that moderate/intense GOLPH3 expression created a significantly prognostic impact in patients with CRPC. On the other hand, multivariate analysis indicated that GOLPH3 was a significantly independent prognostic factor of DFS (<it>P</it> = 0.027) in all prostate cancer patients.</p> <p>Conclusions</p> <p>In this study, it was discovered that the overexpression of GOLPH3 is associated with the transition of prostate cancer from hormone sensitive phase to hormone refractory phase. GOLPH3 might be an important prognostic factor of DFS and OS in patients with prostate cancer. In totality, GOLPH3 could be used as a novel candidate in devising a more effective therapeutic strategy to tackle CRPC.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1452541171722856</url>.</p>http://www.diagnosticpathology.org/content/7/1/127Prostate cancerCastration resistantGolgi phosphoprotein-3PrognosisTissue microarrays
spellingShingle Hua Xing
Yu Lina
Pan Wenhai
Huang Xiaoxiao
Liao Zexiao
Xian Qi
Fang Li
Shen Hong
Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
Diagnostic Pathology
Prostate cancer
Castration resistant
Golgi phosphoprotein-3
Prognosis
Tissue microarrays
title Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
title_full Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
title_fullStr Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
title_full_unstemmed Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
title_short Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
title_sort increased expression of golgi phosphoprotein 3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
topic Prostate cancer
Castration resistant
Golgi phosphoprotein-3
Prognosis
Tissue microarrays
url http://www.diagnosticpathology.org/content/7/1/127
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