Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience
Background: Indolent nature but a high incidence of differentiated thyroid cancer (DTC) remains a challenge for optimizing patient care. Therefore, prognostic factors present valuable information for determining an adequate clinical approach. Methods: This study assessed prognostic features of 1167...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/4/866 |
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| author | Tomislav Jukić Ivan Blažeković Maja Franceschi Petra Petranović Ovčariček Marija Bosak Butković Nina Dabelić Roko Granić Marija Punda Zdenko Sonicki Davor Vagić Ana Fröbe Zvonko Kusić |
| author_facet | Tomislav Jukić Ivan Blažeković Maja Franceschi Petra Petranović Ovčariček Marija Bosak Butković Nina Dabelić Roko Granić Marija Punda Zdenko Sonicki Davor Vagić Ana Fröbe Zvonko Kusić |
| author_sort | Tomislav Jukić |
| collection | DOAJ |
| description | Background: Indolent nature but a high incidence of differentiated thyroid cancer (DTC) remains a challenge for optimizing patient care. Therefore, prognostic factors present valuable information for determining an adequate clinical approach. Methods: This study assessed prognostic features of 1167 papillary (PTC) and 215 follicular (FTC) thyroid cancer patients that had undergone surgery between 1962 and 2012, and were followed-up up to 50 years in a single institution, till April 2020. Age, gender, tumor size, presence of local and distant metastases at presentation, extrathyroidal extension, disease recurrence, and cancer-specific survival were evaluated. Results: In multivariate analysis, factors affecting the worse outcome were age (<i>p</i> = 0.005), tumor size (<i>p</i> = 0.006), and distant metastases (<i>p</i> = 0.001) in PTC, while extrathyroidal extension (<i>p</i> < 0.001), neck recurrence (<i>p</i> = 0.002), and distant metastases (<i>p</i> < 0.001) in FTC patients. Loco-regional recurrence rate was 6% for PTC and 4.7% for FTC patients, while distant metastases were detected in 4.2% PTC and 14.4% of FTC patients. The 10-year cancer-specific survival rates for PTC and FTC were 98.6% and 89.8%, respectively (<i>p</i> < 0.001). Conclusions: Negative prognostic factors, besides distant metastases, were older age and greater tumor size in PTC, and extrathyroidal extension and neck recurrence in FTC patients. The recurrence and mortality rates were very low. |
| first_indexed | 2024-03-09T10:57:03Z |
| format | Article |
| id | doaj.art-327ba6c76c0343c3b40a582db3e77a19 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T10:57:03Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-327ba6c76c0343c3b40a582db3e77a192023-12-01T01:32:01ZengMDPI AGDiagnostics2075-44182022-03-0112486610.3390/diagnostics12040866Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre ExperienceTomislav Jukić0Ivan Blažeković1Maja Franceschi2Petra Petranović Ovčariček3Marija Bosak Butković4Nina Dabelić5Roko Granić6Marija Punda7Zdenko Sonicki8Davor Vagić9Ana Fröbe10Zvonko Kusić11Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaSchool of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, 10000 Zagreb, CroatiaCroatian Academy of Science and Arts, 10000 Zagreb, CroatiaBackground: Indolent nature but a high incidence of differentiated thyroid cancer (DTC) remains a challenge for optimizing patient care. Therefore, prognostic factors present valuable information for determining an adequate clinical approach. Methods: This study assessed prognostic features of 1167 papillary (PTC) and 215 follicular (FTC) thyroid cancer patients that had undergone surgery between 1962 and 2012, and were followed-up up to 50 years in a single institution, till April 2020. Age, gender, tumor size, presence of local and distant metastases at presentation, extrathyroidal extension, disease recurrence, and cancer-specific survival were evaluated. Results: In multivariate analysis, factors affecting the worse outcome were age (<i>p</i> = 0.005), tumor size (<i>p</i> = 0.006), and distant metastases (<i>p</i> = 0.001) in PTC, while extrathyroidal extension (<i>p</i> < 0.001), neck recurrence (<i>p</i> = 0.002), and distant metastases (<i>p</i> < 0.001) in FTC patients. Loco-regional recurrence rate was 6% for PTC and 4.7% for FTC patients, while distant metastases were detected in 4.2% PTC and 14.4% of FTC patients. The 10-year cancer-specific survival rates for PTC and FTC were 98.6% and 89.8%, respectively (<i>p</i> < 0.001). Conclusions: Negative prognostic factors, besides distant metastases, were older age and greater tumor size in PTC, and extrathyroidal extension and neck recurrence in FTC patients. The recurrence and mortality rates were very low.https://www.mdpi.com/2075-4418/12/4/866differentiated thyroid cancerpapillaryfollicularsurvival ratesprognostic featuresrecurrence |
| spellingShingle | Tomislav Jukić Ivan Blažeković Maja Franceschi Petra Petranović Ovčariček Marija Bosak Butković Nina Dabelić Roko Granić Marija Punda Zdenko Sonicki Davor Vagić Ana Fröbe Zvonko Kusić Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience Diagnostics differentiated thyroid cancer papillary follicular survival rates prognostic features recurrence |
| title | Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience |
| title_full | Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience |
| title_fullStr | Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience |
| title_full_unstemmed | Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience |
| title_short | Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience |
| title_sort | long term outcome of differentiated thyroid cancer patients fifty years of croatian thyroid disease referral centre experience |
| topic | differentiated thyroid cancer papillary follicular survival rates prognostic features recurrence |
| url | https://www.mdpi.com/2075-4418/12/4/866 |
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