Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation
Abstract Background Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM pati...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-018-0945-7 |
| _version_ | 1828404068622532608 |
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| author | Hongwei Tian Jingang Cui Chengzhi Yang Fenghuan Hu Jiansong Yuan Shengwen Liu Weixian Yang Xiaowei Jiang Shubin Qiao |
| author_facet | Hongwei Tian Jingang Cui Chengzhi Yang Fenghuan Hu Jiansong Yuan Shengwen Liu Weixian Yang Xiaowei Jiang Shubin Qiao |
| author_sort | Hongwei Tian |
| collection | DOAJ |
| description | Abstract Background Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM patients has not been evaluated yet. We sought to investigate effect of LV remodeling on the presence of AF assessed by cardiovascular magnetic resonance (CMR) in HCM patients. Methods A total of 394 HCM patients were enrolled into this study, including HOCM patients (n = 293) and NOHCM patients (n = 101). Patients were divided into HCM with AF (50) and HCM without AF (n = 344). Data were collected from hospital records. Results LA diameter and LV remodeling index (LVRI) were significantly higher in HCM patients with AF than that of HCM patients without AF (46.6 ± 7.4 mm versus 39.9 ± 8.0 mm, p < 0.001, and 1.46 ± 0.6 versus 1.2 ± 0.4, p = 0.002, respectively). HCM patients with AF were older than HCM patients without AF (53.6 ± 11.7 years versus 47.7 ± 13.6 years, p = 0.002). Additionally, LVRI positively correlated to LA size (r = 0.12, p = 0.02). In a multivariable logistic regression analysis, when adjusting for age and LV end diastolic mass index, LVRI and LA size remained an independent determinant of AF in HCM patients (OR = 4.7, p = 0.001 and OR = 1.13, P < 0.001). Conclusion HCM patients with AF showed significantly more LA diameter, LVRI and age than HCM patients without AF. LVRI and LA size were strong independent predictor of AF in HCM, suggesting LV remodeling may contribute to the occurrence of AF in HCM patients. |
| first_indexed | 2024-12-10T10:29:52Z |
| format | Article |
| id | doaj.art-327ce23f752c4595bac3ba172892c7ac |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-10T10:29:52Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-327ce23f752c4595bac3ba172892c7ac2022-12-22T01:52:36ZengBMCBMC Cardiovascular Disorders1471-22612018-11-011811610.1186/s12872-018-0945-7Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillationHongwei Tian0Jingang Cui1Chengzhi Yang2Fenghuan Hu3Jiansong Yuan4Shengwen Liu5Weixian Yang6Xiaowei Jiang7Shubin Qiao8State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background Atrial fibrillation (AF) is the most common complication in hypertrophic cardiomyopathy (HCM). The mechanisms of AF is associated with left atrial (LA) structural remodeling in HCM patients. However, the impact of left ventricular (LV) remodeling on the presence of AF in HCM patients has not been evaluated yet. We sought to investigate effect of LV remodeling on the presence of AF assessed by cardiovascular magnetic resonance (CMR) in HCM patients. Methods A total of 394 HCM patients were enrolled into this study, including HOCM patients (n = 293) and NOHCM patients (n = 101). Patients were divided into HCM with AF (50) and HCM without AF (n = 344). Data were collected from hospital records. Results LA diameter and LV remodeling index (LVRI) were significantly higher in HCM patients with AF than that of HCM patients without AF (46.6 ± 7.4 mm versus 39.9 ± 8.0 mm, p < 0.001, and 1.46 ± 0.6 versus 1.2 ± 0.4, p = 0.002, respectively). HCM patients with AF were older than HCM patients without AF (53.6 ± 11.7 years versus 47.7 ± 13.6 years, p = 0.002). Additionally, LVRI positively correlated to LA size (r = 0.12, p = 0.02). In a multivariable logistic regression analysis, when adjusting for age and LV end diastolic mass index, LVRI and LA size remained an independent determinant of AF in HCM patients (OR = 4.7, p = 0.001 and OR = 1.13, P < 0.001). Conclusion HCM patients with AF showed significantly more LA diameter, LVRI and age than HCM patients without AF. LVRI and LA size were strong independent predictor of AF in HCM, suggesting LV remodeling may contribute to the occurrence of AF in HCM patients.http://link.springer.com/article/10.1186/s12872-018-0945-7Atrial fibrillationHypertrophic cardiomyopathyLeft ventricular remodeling |
| spellingShingle | Hongwei Tian Jingang Cui Chengzhi Yang Fenghuan Hu Jiansong Yuan Shengwen Liu Weixian Yang Xiaowei Jiang Shubin Qiao Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation BMC Cardiovascular Disorders Atrial fibrillation Hypertrophic cardiomyopathy Left ventricular remodeling |
| title | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
| title_full | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
| title_fullStr | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
| title_full_unstemmed | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
| title_short | Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
| title_sort | left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation |
| topic | Atrial fibrillation Hypertrophic cardiomyopathy Left ventricular remodeling |
| url | http://link.springer.com/article/10.1186/s12872-018-0945-7 |
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