Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia.
The primary objective was to describe infectious complications in children with acute myeloid leukemia from presentation to the healthcare system to initiation of chemotherapy and to describe how these infections differ depending on neutropenia.We conducted a retrospective, population-based cohort s...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3637321?pdf=render |
| _version_ | 1811207976169504768 |
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| author | Carol Portwine David Mitchell Donna Johnston Biljana Gillmeister Marie-Chantal Ethier Rochelle Yanofsky David Dix Sonia Cellot Victor Lewis Victoria Price Mariana Silva Shayna Zelcer Lynette Bowes Bruno Michon Kent Stobart Josee Brossard Joseph Beyene Lillian Sung |
| author_facet | Carol Portwine David Mitchell Donna Johnston Biljana Gillmeister Marie-Chantal Ethier Rochelle Yanofsky David Dix Sonia Cellot Victor Lewis Victoria Price Mariana Silva Shayna Zelcer Lynette Bowes Bruno Michon Kent Stobart Josee Brossard Joseph Beyene Lillian Sung |
| author_sort | Carol Portwine |
| collection | DOAJ |
| description | The primary objective was to describe infectious complications in children with acute myeloid leukemia from presentation to the healthcare system to initiation of chemotherapy and to describe how these infections differ depending on neutropenia.We conducted a retrospective, population-based cohort study that included children and adolescents with acute myeloid leukemia diagnosed and treated at 15 Canadian centers. We evaluated infections that occurred between presentation to the healthcare system (for symptoms that led to the diagnosis of acute myeloid leukemia) until initiation of chemotherapy.Among 328 children, 92 (28.0%) were neutropenic at presentation. Eleven (3.4%) had sterile-site microbiologically documented infection and four had bacteremia (only one Gram negative). Infection rate was not influenced by neutropenia. No child died from an infectious cause prior to chemotherapy initiation.It may be reasonable to withhold empiric antibiotics in febrile non-neutropenic children with newly diagnosed acute myeloid leukemia until initiation of chemotherapy as long as they appear well without a clinical focus of infection. Future work could examine biomarkers or a clinical score to identify children presenting with leukemia and fever who are more likely to have an invasive infection. |
| first_indexed | 2024-04-12T04:14:18Z |
| format | Article |
| id | doaj.art-327d7d3983154da89445ce2bf95a6b79 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T04:14:18Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-327d7d3983154da89445ce2bf95a6b792022-12-22T03:48:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6189910.1371/journal.pone.0061899Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia.Carol PortwineDavid MitchellDonna JohnstonBiljana GillmeisterMarie-Chantal EthierRochelle YanofskyDavid DixSonia CellotVictor LewisVictoria PriceMariana SilvaShayna ZelcerLynette BowesBruno MichonKent StobartJosee BrossardJoseph BeyeneLillian SungThe primary objective was to describe infectious complications in children with acute myeloid leukemia from presentation to the healthcare system to initiation of chemotherapy and to describe how these infections differ depending on neutropenia.We conducted a retrospective, population-based cohort study that included children and adolescents with acute myeloid leukemia diagnosed and treated at 15 Canadian centers. We evaluated infections that occurred between presentation to the healthcare system (for symptoms that led to the diagnosis of acute myeloid leukemia) until initiation of chemotherapy.Among 328 children, 92 (28.0%) were neutropenic at presentation. Eleven (3.4%) had sterile-site microbiologically documented infection and four had bacteremia (only one Gram negative). Infection rate was not influenced by neutropenia. No child died from an infectious cause prior to chemotherapy initiation.It may be reasonable to withhold empiric antibiotics in febrile non-neutropenic children with newly diagnosed acute myeloid leukemia until initiation of chemotherapy as long as they appear well without a clinical focus of infection. Future work could examine biomarkers or a clinical score to identify children presenting with leukemia and fever who are more likely to have an invasive infection.http://europepmc.org/articles/PMC3637321?pdf=render |
| spellingShingle | Carol Portwine David Mitchell Donna Johnston Biljana Gillmeister Marie-Chantal Ethier Rochelle Yanofsky David Dix Sonia Cellot Victor Lewis Victoria Price Mariana Silva Shayna Zelcer Lynette Bowes Bruno Michon Kent Stobart Josee Brossard Joseph Beyene Lillian Sung Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. PLoS ONE |
| title | Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. |
| title_full | Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. |
| title_fullStr | Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. |
| title_full_unstemmed | Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. |
| title_short | Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia. |
| title_sort | infectious events prior to chemotherapy initiation in children with acute myeloid leukemia |
| url | http://europepmc.org/articles/PMC3637321?pdf=render |
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