MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis

MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis

Schistosomiasis is a chronic disease caused by the parasite of the Schistosoma genus and is characterized by egg-induced hepatic granulomas and fibrosis. Macrophages play a central role in schistosomiasis with several studies highlighting their differentiation into M2 cells involved in the survival...

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Bibliographic Details
Main Authors: Xing He, Rui Tang, Yue Sun, Yan-Ge Wang, Kui-Yang Zhen, Dong-Mei Zhang, Wei-Qing Pan
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
miR-146
macrophage differentiation
hepatic schistosomiasis
STAT pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304856

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