<i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions
Dogs and cats may suffer from a variety of diseases, mainly immune mediated, that require the administration of immunosuppressive drugs. Such therapies can cause adverse effects either by the toxicity of the drugs or as a consequence of immune suppression and associated opportunistic infections. Her...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/1/114 |
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| author | Radu Blaga Virginie Fabres Vincent Leynaud Jean-Jacques Fontaine Edouard Reyes-Gomez Amaury Briand Odile Crosaz Isabelle Lagrange Amandine Blaizot Delphine Le Roux Veronica Risco Castillo Pavlo Maksimov Jacques Guillot Jens Peter Teifke Gereon Schares |
| author_facet | Radu Blaga Virginie Fabres Vincent Leynaud Jean-Jacques Fontaine Edouard Reyes-Gomez Amaury Briand Odile Crosaz Isabelle Lagrange Amandine Blaizot Delphine Le Roux Veronica Risco Castillo Pavlo Maksimov Jacques Guillot Jens Peter Teifke Gereon Schares |
| author_sort | Radu Blaga |
| collection | DOAJ |
| description | Dogs and cats may suffer from a variety of diseases, mainly immune mediated, that require the administration of immunosuppressive drugs. Such therapies can cause adverse effects either by the toxicity of the drugs or as a consequence of immune suppression and associated opportunistic infections. Here we present an, yet unknown, association of <i>Toxoplasma gondii</i> and <i>Alternaria</i> fungus, within cutaneous lesions in a dog under long-term immunosuppressive therapy. The diagnosis of such infections is laborious and not obvious at first glance, since the clinical signs of cutaneous toxoplasmosis, neosporosis or alternariosis are not specific. A further laboratory confirmation is needed. Therefore, we currently recommend that dogs and cats should undergo serologic testing for toxoplasmosis or neosporosis prior to immunosuppressive therapy and a regular dermatological evaluation during the immunosuppressive therapy. |
| first_indexed | 2024-03-09T11:29:19Z |
| format | Article |
| id | doaj.art-328371698720474395cb4e8e61439d6e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T11:29:19Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-328371698720474395cb4e8e61439d6e2023-11-30T23:53:54ZengMDPI AGPathogens2076-08172023-01-0112111410.3390/pathogens12010114<i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin LesionsRadu Blaga0Virginie Fabres1Vincent Leynaud2Jean-Jacques Fontaine3Edouard Reyes-Gomez4Amaury Briand5Odile Crosaz6Isabelle Lagrange7Amandine Blaizot8Delphine Le Roux9Veronica Risco Castillo10Pavlo Maksimov11Jacques Guillot12Jens Peter Teifke13Gereon Schares14Anses, INRAE, Ecole Nationale Vétérinaire d’Alfort, Laboratoire de Santé Animale, BIPAR, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, CHUVA, Unité de Médecine, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, CHUVA, Unité de Médecine, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, BioPôle, Laboratoire d’anatomo-cytopathologie, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, BioPôle, Laboratoire d’anatomo-cytopathologie, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, CHUVA, Unité de Dermatologie, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, CHUVA, Unité de Dermatologie, F-94700 Maisons-Alfort, FranceEcole Nationale Vétérinaire d’Alfort, Biopôle, Laboratoire de Biochimie-hématologie, F-94700 Maisons-Alfort, FranceAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, Laboratoire de Santé Animale, BIPAR, F-94700 Maisons-Alfort, FranceAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, Laboratoire de Santé Animale, BIPAR, F-94700 Maisons-Alfort, FranceAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, Laboratoire de Santé Animale, BIPAR, F-94700 Maisons-Alfort, FranceInstitute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald, GermanyOniris, Department of Dermatology, Parasitology, Mycology, F-44300 Nantes, FranceDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald, GermanyInstitute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald, GermanyDogs and cats may suffer from a variety of diseases, mainly immune mediated, that require the administration of immunosuppressive drugs. Such therapies can cause adverse effects either by the toxicity of the drugs or as a consequence of immune suppression and associated opportunistic infections. Here we present an, yet unknown, association of <i>Toxoplasma gondii</i> and <i>Alternaria</i> fungus, within cutaneous lesions in a dog under long-term immunosuppressive therapy. The diagnosis of such infections is laborious and not obvious at first glance, since the clinical signs of cutaneous toxoplasmosis, neosporosis or alternariosis are not specific. A further laboratory confirmation is needed. Therefore, we currently recommend that dogs and cats should undergo serologic testing for toxoplasmosis or neosporosis prior to immunosuppressive therapy and a regular dermatological evaluation during the immunosuppressive therapy.https://www.mdpi.com/2076-0817/12/1/114<i>Toxoplasma gondii</i><i>Alternaria</i>immunosuppressive therapyskin lesions |
| spellingShingle | Radu Blaga Virginie Fabres Vincent Leynaud Jean-Jacques Fontaine Edouard Reyes-Gomez Amaury Briand Odile Crosaz Isabelle Lagrange Amandine Blaizot Delphine Le Roux Veronica Risco Castillo Pavlo Maksimov Jacques Guillot Jens Peter Teifke Gereon Schares <i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions Pathogens <i>Toxoplasma gondii</i> <i>Alternaria</i> immunosuppressive therapy skin lesions |
| title | <i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions |
| title_full | <i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions |
| title_fullStr | <i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions |
| title_full_unstemmed | <i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions |
| title_short | <i>Toxoplasma gondii</i> and <i>Alternaria</i> sp.: An Original Association in an Immunosuppressed Dog with Persistent Skin Lesions |
| title_sort | i toxoplasma gondii i and i alternaria i sp an original association in an immunosuppressed dog with persistent skin lesions |
| topic | <i>Toxoplasma gondii</i> <i>Alternaria</i> immunosuppressive therapy skin lesions |
| url | https://www.mdpi.com/2076-0817/12/1/114 |
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