Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature
Abstract Mesothelioma, with various clinical manifestations, radiological features, and histomorphological types, can be divided into epithelioid, sarcomatoid, and biphasic types, according to their histomorphological characteristics. There is a rare growth pattern of pleural mesothelioma: diffuse i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-023-01327-7 |
| _version_ | 1827943582940528640 |
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| author | Wang RanYue Wu ChunYan Hou Likun Zhang LiPing Lin JieLu Dong ZhengWei |
| author_facet | Wang RanYue Wu ChunYan Hou Likun Zhang LiPing Lin JieLu Dong ZhengWei |
| author_sort | Wang RanYue |
| collection | DOAJ |
| description | Abstract Mesothelioma, with various clinical manifestations, radiological features, and histomorphological types, can be divided into epithelioid, sarcomatoid, and biphasic types, according to their histomorphological characteristics. There is a rare growth pattern of pleural mesothelioma: diffuse intrapulmonary mesothelioma (DIM), with a distinctive pattern of predominantly intrapulmonary growth, has no or minimal pleural involvement, and simulates interstitial lung disease(ILD) clinically and radiologically. A 59-year-old man presented to the hospital with recurrent pleural effusions for 4 years and a history of asbestos exposure. Computed tomography (CT) showed bilateral pure ground-glass opacity lesions, and the tumor cells showed a lepidic growth pattern pathologically. Immunohistochemical staining was positive for CK, WT-1, calretinin, D2-40, CK5/6, and Claudin4, while TTF-1, CEA, EMA, CK7, CK20, and other epithelial markers were negative. BAP1 loss its expression, and MTAP was positive in cytoplasm. CDKN2A was negative tested by Fluorescence in situ hybridization (FISH). The final diagnosis was DIM. In conclusion, we should recognize this rare disease to avoid misdiagnosis and delayed treatment. |
| first_indexed | 2024-03-13T10:17:48Z |
| format | Article |
| id | doaj.art-3283cc3f38224c2b97f4df05ba245c66 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-03-13T10:17:48Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-3283cc3f38224c2b97f4df05ba245c662023-05-21T11:06:39ZengBMCDiagnostic Pathology1746-15962023-05-011811910.1186/s13000-023-01327-7Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literatureWang RanYue0Wu ChunYan1Hou Likun2Zhang LiPing3Lin JieLu4Dong ZhengWei5Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of MedicineAbstract Mesothelioma, with various clinical manifestations, radiological features, and histomorphological types, can be divided into epithelioid, sarcomatoid, and biphasic types, according to their histomorphological characteristics. There is a rare growth pattern of pleural mesothelioma: diffuse intrapulmonary mesothelioma (DIM), with a distinctive pattern of predominantly intrapulmonary growth, has no or minimal pleural involvement, and simulates interstitial lung disease(ILD) clinically and radiologically. A 59-year-old man presented to the hospital with recurrent pleural effusions for 4 years and a history of asbestos exposure. Computed tomography (CT) showed bilateral pure ground-glass opacity lesions, and the tumor cells showed a lepidic growth pattern pathologically. Immunohistochemical staining was positive for CK, WT-1, calretinin, D2-40, CK5/6, and Claudin4, while TTF-1, CEA, EMA, CK7, CK20, and other epithelial markers were negative. BAP1 loss its expression, and MTAP was positive in cytoplasm. CDKN2A was negative tested by Fluorescence in situ hybridization (FISH). The final diagnosis was DIM. In conclusion, we should recognize this rare disease to avoid misdiagnosis and delayed treatment.https://doi.org/10.1186/s13000-023-01327-7MesotheliomaDiffuse intrapulmonary mesotheliomaPleuraAdenocarcinomaLepidicLung cancer |
| spellingShingle | Wang RanYue Wu ChunYan Hou Likun Zhang LiPing Lin JieLu Dong ZhengWei Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature Diagnostic Pathology Mesothelioma Diffuse intrapulmonary mesothelioma Pleura Adenocarcinoma Lepidic Lung cancer |
| title | Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature |
| title_full | Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature |
| title_fullStr | Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature |
| title_full_unstemmed | Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature |
| title_short | Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature |
| title_sort | diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma a rare case report and review of the literature |
| topic | Mesothelioma Diffuse intrapulmonary mesothelioma Pleura Adenocarcinoma Lepidic Lung cancer |
| url | https://doi.org/10.1186/s13000-023-01327-7 |
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