Exercise intensity governs tumor control in mice with breast cancer
IntroductionExercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity.MethodsWe subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) g...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1339232/full |
| _version_ | 1797289791188893696 |
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| author | Igor L. Gomes-Santos Ashwin S. Kumar Ashwin S. Kumar Franziska Hausmann Max N. Meyer Sarah Z. Shiferaw Zohreh Amoozgar Rakesh K. Jain Dai Fukumura |
| author_facet | Igor L. Gomes-Santos Ashwin S. Kumar Ashwin S. Kumar Franziska Hausmann Max N. Meyer Sarah Z. Shiferaw Zohreh Amoozgar Rakesh K. Jain Dai Fukumura |
| author_sort | Igor L. Gomes-Santos |
| collection | DOAJ |
| description | IntroductionExercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity.MethodsWe subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) groups based on their individual maximal running capacity.ResultsWe found that exercise intensity played a critical role in tumor control. Only Mi exercise delayed tumor growth and reduced tumor burden, whereas Li or Hi exercise failed to exert similar antitumor effects. While both Li and Mi exercise normalized the tumor vasculature, only Mi exercise increased tumor infiltrated CD8+ T cells, that also displayed enhanced effector function (higher proliferation and expression of CD69, INFγ, GzmB). Moreover, exercise induced an intensity-dependent mobilization of CD8+ T cells into the bloodstream.ConclusionThese findings shed light on the intricate relationship between exercise intensity and cancer, with implications for personalized and optimal exercise prescriptions for tumor control. |
| first_indexed | 2024-03-07T19:10:09Z |
| format | Article |
| id | doaj.art-3286f5901d15482c9df4530aa3a8ab72 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T19:10:09Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3286f5901d15482c9df4530aa3a8ab722024-03-01T04:25:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13392321339232Exercise intensity governs tumor control in mice with breast cancerIgor L. Gomes-Santos0Ashwin S. Kumar1Ashwin S. Kumar2Franziska Hausmann3Max N. Meyer4Sarah Z. Shiferaw5Zohreh Amoozgar6Rakesh K. Jain7Dai Fukumura8Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesHarvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United StatesIntroductionExercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity.MethodsWe subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) groups based on their individual maximal running capacity.ResultsWe found that exercise intensity played a critical role in tumor control. Only Mi exercise delayed tumor growth and reduced tumor burden, whereas Li or Hi exercise failed to exert similar antitumor effects. While both Li and Mi exercise normalized the tumor vasculature, only Mi exercise increased tumor infiltrated CD8+ T cells, that also displayed enhanced effector function (higher proliferation and expression of CD69, INFγ, GzmB). Moreover, exercise induced an intensity-dependent mobilization of CD8+ T cells into the bloodstream.ConclusionThese findings shed light on the intricate relationship between exercise intensity and cancer, with implications for personalized and optimal exercise prescriptions for tumor control.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1339232/fullexercisebreast cancerexercise intensitytumor microenvironmentimmunityCD8+ T cells |
| spellingShingle | Igor L. Gomes-Santos Ashwin S. Kumar Ashwin S. Kumar Franziska Hausmann Max N. Meyer Sarah Z. Shiferaw Zohreh Amoozgar Rakesh K. Jain Dai Fukumura Exercise intensity governs tumor control in mice with breast cancer Frontiers in Immunology exercise breast cancer exercise intensity tumor microenvironment immunity CD8+ T cells |
| title | Exercise intensity governs tumor control in mice with breast cancer |
| title_full | Exercise intensity governs tumor control in mice with breast cancer |
| title_fullStr | Exercise intensity governs tumor control in mice with breast cancer |
| title_full_unstemmed | Exercise intensity governs tumor control in mice with breast cancer |
| title_short | Exercise intensity governs tumor control in mice with breast cancer |
| title_sort | exercise intensity governs tumor control in mice with breast cancer |
| topic | exercise breast cancer exercise intensity tumor microenvironment immunity CD8+ T cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1339232/full |
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