A systematic review of associations between gut microbiota composition and growth failure in preterm neonates
ABSTRACTGrowth failure is among the most prevalent and devastating consequences of prematurity. Up to half of all extremely preterm neonates struggle to grow despite modern nutrition practices. Although elegant preclinical models suggest causal roles for the gut microbiome, these insights have not y...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2190301 |
| _version_ | 1797236635661762560 |
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| author | Larissa L. Neves Amy B. Hair Geoffrey A. Preidis |
| author_facet | Larissa L. Neves Amy B. Hair Geoffrey A. Preidis |
| author_sort | Larissa L. Neves |
| collection | DOAJ |
| description | ABSTRACTGrowth failure is among the most prevalent and devastating consequences of prematurity. Up to half of all extremely preterm neonates struggle to grow despite modern nutrition practices. Although elegant preclinical models suggest causal roles for the gut microbiome, these insights have not yet translated into biomarkers that identify at-risk neonates or therapies that prevent or treat growth failure. This systematic review aims to identify features of the neonatal gut microbiota that are positively or negatively associated with early postnatal growth. We identified 860 articles, of which 14 were eligible for inclusion. No two studies used the same definitions of growth, ages at stool collection, and statistical methods linking microbiota to metadata. In all, 58 different taxa were associated with growth, with little consensus among studies. Two or more studies reported positive associations with Enterobacteriaceae, Bacteroides, Bifidobacterium, Enterococcus, and Veillonella, and negative associations with Citrobacter, Klebsiella, and Staphylococcus. Streptococcus was positively associated with growth in five studies and negatively associated with growth in three studies. To gain insight into how the various definitions of growth could impact results, we performed an exploratory secondary analysis of 245 longitudinally sampled preterm infant stools, linking microbiota composition to multiple clinically relevant definitions of neonatal growth. Within this cohort, every definition of growth was associated with a different combination of microbiota features. Together, these results suggest that the lack of consensus in defining neonatal growth may limit our capacity to detect consistent, meaningful clinical associations that could be leveraged into improved care for preterm neonates. |
| first_indexed | 2024-03-11T14:19:52Z |
| format | Article |
| id | doaj.art-3287e105f76d46e59f18f57594574fc1 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:06:59Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-3287e105f76d46e59f18f57594574fc12024-03-28T22:38:21ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2190301A systematic review of associations between gut microbiota composition and growth failure in preterm neonatesLarissa L. Neves0Amy B. Hair1Geoffrey A. Preidis2Division of Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USADivision of Neonatology, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USADivision of Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USAABSTRACTGrowth failure is among the most prevalent and devastating consequences of prematurity. Up to half of all extremely preterm neonates struggle to grow despite modern nutrition practices. Although elegant preclinical models suggest causal roles for the gut microbiome, these insights have not yet translated into biomarkers that identify at-risk neonates or therapies that prevent or treat growth failure. This systematic review aims to identify features of the neonatal gut microbiota that are positively or negatively associated with early postnatal growth. We identified 860 articles, of which 14 were eligible for inclusion. No two studies used the same definitions of growth, ages at stool collection, and statistical methods linking microbiota to metadata. In all, 58 different taxa were associated with growth, with little consensus among studies. Two or more studies reported positive associations with Enterobacteriaceae, Bacteroides, Bifidobacterium, Enterococcus, and Veillonella, and negative associations with Citrobacter, Klebsiella, and Staphylococcus. Streptococcus was positively associated with growth in five studies and negatively associated with growth in three studies. To gain insight into how the various definitions of growth could impact results, we performed an exploratory secondary analysis of 245 longitudinally sampled preterm infant stools, linking microbiota composition to multiple clinically relevant definitions of neonatal growth. Within this cohort, every definition of growth was associated with a different combination of microbiota features. Together, these results suggest that the lack of consensus in defining neonatal growth may limit our capacity to detect consistent, meaningful clinical associations that could be leveraged into improved care for preterm neonates.https://www.tandfonline.com/doi/10.1080/19490976.2023.2190301Growth failuregut microbiomemalnutritionneonatepostnatal growthpreterm infant |
| spellingShingle | Larissa L. Neves Amy B. Hair Geoffrey A. Preidis A systematic review of associations between gut microbiota composition and growth failure in preterm neonates Gut Microbes Growth failure gut microbiome malnutrition neonate postnatal growth preterm infant |
| title | A systematic review of associations between gut microbiota composition and growth failure in preterm neonates |
| title_full | A systematic review of associations between gut microbiota composition and growth failure in preterm neonates |
| title_fullStr | A systematic review of associations between gut microbiota composition and growth failure in preterm neonates |
| title_full_unstemmed | A systematic review of associations between gut microbiota composition and growth failure in preterm neonates |
| title_short | A systematic review of associations between gut microbiota composition and growth failure in preterm neonates |
| title_sort | systematic review of associations between gut microbiota composition and growth failure in preterm neonates |
| topic | Growth failure gut microbiome malnutrition neonate postnatal growth preterm infant |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2190301 |
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