The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils

The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils

Neutrophils play major roles against bacteria and fungi infections not only due to their microbicide properties but also because they release mediators like Interleukin-1 beta (IL-1β) that contribute to orchestrate the inflammatory response. This cytokine is a leaderless protein synthesized in the c...

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Bibliographic Details
Main Authors: Irene A. Keitelman, Carolina M. Shiromizu, Nadia R. Zgajnar, Silvia Danielián, Carolina C. Jancic, Marcelo A. Martí, Federico Fuentes, Judith Yancoski, Douglas Vera Aguilar, David A. Rosso, Verónica Goris, Guadalupe Buda, María Martha Katsicas, Mario D. Galigniana, Jeremías G. Galletti, Florencia Sabbione, Analia S. Trevani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
autophagosome
granulocytes
inflammasome
neutral proteases
unconventional protein secretion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.832306/full

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