CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
<p>Abstract</p> <p>Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2006-04-01
|
| Series: | Molecular Pain |
| Online Access: | http://www.molecularpain.com/content/2/1/15 |
| _version_ | 1818493382016630784 |
|---|---|
| author | Zhuo Min Ko Shanelle W Ao Hushan |
| author_facet | Zhuo Min Ko Shanelle W Ao Hushan |
| author_sort | Zhuo Min |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.</p> |
| first_indexed | 2024-12-10T17:54:25Z |
| format | Article |
| id | doaj.art-3289d78cea1348d4ac38dde11106f659 |
| institution | Directory Open Access Journal |
| issn | 1744-8069 |
| language | English |
| last_indexed | 2024-12-10T17:54:25Z |
| publishDate | 2006-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Pain |
| spelling | doaj.art-3289d78cea1348d4ac38dde11106f6592022-12-22T01:38:58ZengSAGE PublishingMolecular Pain1744-80692006-04-01211510.1186/1744-8069-2-15CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brainZhuo MinKo Shanelle WAo Hushan<p>Abstract</p> <p>Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.</p>http://www.molecularpain.com/content/2/1/15 |
| spellingShingle | Zhuo Min Ko Shanelle W Ao Hushan CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain Molecular Pain |
| title | CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain |
| title_full | CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain |
| title_fullStr | CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain |
| title_full_unstemmed | CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain |
| title_short | CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain |
| title_sort | creb activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain |
| url | http://www.molecularpain.com/content/2/1/15 |
| work_keys_str_mv | AT zhuomin crebactivitymaintainsthesurvivalofcingulatecorticalpyramidalneuronsintheadultmousebrain AT koshanellew crebactivitymaintainsthesurvivalofcingulatecorticalpyramidalneuronsintheadultmousebrain AT aohushan crebactivitymaintainsthesurvivalofcingulatecorticalpyramidalneuronsintheadultmousebrain |