A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism

A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism

Chronic alpha-synuclein (SNCA) overexpression is a relatively homogenous and well-defined cause of parkinsonism and dementia. Parkinson's disease (PD), PD with dementia, dementia with Lewy bodies and multiple system atrophy all manifest in SNCA multiplication families. Herein we summarize genea...

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Bibliographic Details
Main Authors: Adam Book, Ilaria Guella, Tara Candido, Alexis Brice, Nobutaka Hattori, Beomseok Jeon, Matthew J. Farrer, SNCA Multiplication Investigators of the GEoPD Consortium
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neurology
Subjects:
SNCA
duplication
triplication
parkinsonism
dementia
clinical phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.01021/full

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