Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases
B-cell development is a very orchestrated pathway that involves several molecules, such as transcription factors, cytokines, microRNAs, and also different cells. All these components maintain the ideal microenvironment and control B-cell differentiation. MicroRNAs are small non-coding RNAs that bind...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/2004 |
| _version_ | 1797411079682260992 |
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| author | Olívia Fonseca Souza Ana Flavia Popi |
| author_facet | Olívia Fonseca Souza Ana Flavia Popi |
| author_sort | Olívia Fonseca Souza |
| collection | DOAJ |
| description | B-cell development is a very orchestrated pathway that involves several molecules, such as transcription factors, cytokines, microRNAs, and also different cells. All these components maintain the ideal microenvironment and control B-cell differentiation. MicroRNAs are small non-coding RNAs that bind to target mRNA to control gene expression. These molecules could circulate in the body in a free form, protein-bounded, or encapsulated into extracellular vesicles, such as exosomes. The comprehension of the role of microRNAs in the B-cell development was possible based on microRNA profile of each B-cell stage and functional studies. Herein, we report the knowledge about microRNAs in the B-cell the differentiation, proliferation, and also in hematological malignancies. |
| first_indexed | 2024-03-09T04:39:50Z |
| format | Article |
| id | doaj.art-328b7d03f23449c5872ee90a701f1802 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T04:39:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-328b7d03f23449c5872ee90a701f18022023-12-03T13:22:07ZengMDPI AGBiomedicines2227-90592022-08-01108200410.3390/biomedicines10082004Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological DiseasesOlívia Fonseca Souza0Ana Flavia Popi1Disciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo 04039-032, BrazilDisciplina de Imunologia, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo 04039-032, BrazilB-cell development is a very orchestrated pathway that involves several molecules, such as transcription factors, cytokines, microRNAs, and also different cells. All these components maintain the ideal microenvironment and control B-cell differentiation. MicroRNAs are small non-coding RNAs that bind to target mRNA to control gene expression. These molecules could circulate in the body in a free form, protein-bounded, or encapsulated into extracellular vesicles, such as exosomes. The comprehension of the role of microRNAs in the B-cell development was possible based on microRNA profile of each B-cell stage and functional studies. Herein, we report the knowledge about microRNAs in the B-cell the differentiation, proliferation, and also in hematological malignancies.https://www.mdpi.com/2227-9059/10/8/2004microRNAsB-cellhematological B malignanciesexosomes |
| spellingShingle | Olívia Fonseca Souza Ana Flavia Popi Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases Biomedicines microRNAs B-cell hematological B malignancies exosomes |
| title | Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases |
| title_full | Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases |
| title_fullStr | Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases |
| title_full_unstemmed | Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases |
| title_short | Role of microRNAs in B-Cell Compartment: Development, Proliferation and Hematological Diseases |
| title_sort | role of micrornas in b cell compartment development proliferation and hematological diseases |
| topic | microRNAs B-cell hematological B malignancies exosomes |
| url | https://www.mdpi.com/2227-9059/10/8/2004 |
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