New insights into the functions of enamel matrices in calcified tissues
Ameloblasts secrete enamel matrix proteins, including amelogenin, ameloblastin, enamelin, amelotin, and Apin/odontogenic ameloblast-associated protein (Apin/ODAM). Amelogenin is the major protein component of the enamel matrix. Amelogenin, ameloblastin, and enamelin are expressed during the secretor...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-05-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761614000027 |
| _version_ | 1811323443625328640 |
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| author | Satoshi Fukumoto Takashi Nakamura Aya Yamada Makiko Arakaki Kan Saito Juan Xu Emiko Fukumoto Yoshihiko Yamada |
| author_facet | Satoshi Fukumoto Takashi Nakamura Aya Yamada Makiko Arakaki Kan Saito Juan Xu Emiko Fukumoto Yoshihiko Yamada |
| author_sort | Satoshi Fukumoto |
| collection | DOAJ |
| description | Ameloblasts secrete enamel matrix proteins, including amelogenin, ameloblastin, enamelin, amelotin, and Apin/odontogenic ameloblast-associated protein (Apin/ODAM). Amelogenin is the major protein component of the enamel matrix. Amelogenin, ameloblastin, and enamelin are expressed during the secretory stage of ameloblast, while amelotin and Apin/ODAM are expressed during the maturation. Amelogenin and ameloblastin are also expressed in osteoblasts, and they regulate bone formation. In addition, recent studies show the importance of protein–protein interactions between enamel matrix components for enamel formation. In a mouse model mimicking a mutation of the amelogenin gene in amelogenesis imperfect (AI) in humans, the mutated amelogenin forms a complex with ameloblastin, which accumulates in the endoplasmic reticulum/Golgi apparatus and causes ameloblast dysfunction resulting in AI phenotypes. Ameloblastin is a cell adhesion molecule that regulates cell proliferation. It inhibits odontogenic tumor formation and regulates osteoblast differentiation through binding to CD63. Amelotin interacts with Apin/ODAM, but not ameloblastin, while Apin/ODAM binds to ameloblastin. These interactions may be important for enamel mineralization during amelogenesis. The enamel matrix genes are clustered on human chromosome 4 except for the amelogenin genes located on the sex chromosomes. Genes for these enamel matrix proteins evolved from a common ancestral gene encoding secretory calcium-binding phosphoprotein. |
| first_indexed | 2024-04-13T13:54:10Z |
| format | Article |
| id | doaj.art-32902873da394141aaaa74340ec87816 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-04-13T13:54:10Z |
| publishDate | 2014-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-32902873da394141aaaa74340ec878162022-12-22T02:44:14ZengElsevierJapanese Dental Science Review1882-76162014-05-01502475410.1016/j.jdsr.2014.01.001New insights into the functions of enamel matrices in calcified tissuesSatoshi Fukumoto0Takashi Nakamura1Aya Yamada2Makiko Arakaki3Kan Saito4Juan Xu5Emiko Fukumoto6Yoshihiko Yamada7Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, JapanDivision of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, JapanDivision of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, JapanDivision of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, JapanDivision of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, JapanLaboratory of Cell and Developmental Biology, NIDCR, National Institutes of Health, Bethesda, MD 20892, USADivision of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, JapanLaboratory of Cell and Developmental Biology, NIDCR, National Institutes of Health, Bethesda, MD 20892, USAAmeloblasts secrete enamel matrix proteins, including amelogenin, ameloblastin, enamelin, amelotin, and Apin/odontogenic ameloblast-associated protein (Apin/ODAM). Amelogenin is the major protein component of the enamel matrix. Amelogenin, ameloblastin, and enamelin are expressed during the secretory stage of ameloblast, while amelotin and Apin/ODAM are expressed during the maturation. Amelogenin and ameloblastin are also expressed in osteoblasts, and they regulate bone formation. In addition, recent studies show the importance of protein–protein interactions between enamel matrix components for enamel formation. In a mouse model mimicking a mutation of the amelogenin gene in amelogenesis imperfect (AI) in humans, the mutated amelogenin forms a complex with ameloblastin, which accumulates in the endoplasmic reticulum/Golgi apparatus and causes ameloblast dysfunction resulting in AI phenotypes. Ameloblastin is a cell adhesion molecule that regulates cell proliferation. It inhibits odontogenic tumor formation and regulates osteoblast differentiation through binding to CD63. Amelotin interacts with Apin/ODAM, but not ameloblastin, while Apin/ODAM binds to ameloblastin. These interactions may be important for enamel mineralization during amelogenesis. The enamel matrix genes are clustered on human chromosome 4 except for the amelogenin genes located on the sex chromosomes. Genes for these enamel matrix proteins evolved from a common ancestral gene encoding secretory calcium-binding phosphoprotein.http://www.sciencedirect.com/science/article/pii/S1882761614000027Enamel matrixAmelogeninAmeloblastinEnamelinAmelotinOdontogenic ameloblast-associated proteinApin |
| spellingShingle | Satoshi Fukumoto Takashi Nakamura Aya Yamada Makiko Arakaki Kan Saito Juan Xu Emiko Fukumoto Yoshihiko Yamada New insights into the functions of enamel matrices in calcified tissues Japanese Dental Science Review Enamel matrix Amelogenin Ameloblastin Enamelin Amelotin Odontogenic ameloblast-associated protein Apin |
| title | New insights into the functions of enamel matrices in calcified tissues |
| title_full | New insights into the functions of enamel matrices in calcified tissues |
| title_fullStr | New insights into the functions of enamel matrices in calcified tissues |
| title_full_unstemmed | New insights into the functions of enamel matrices in calcified tissues |
| title_short | New insights into the functions of enamel matrices in calcified tissues |
| title_sort | new insights into the functions of enamel matrices in calcified tissues |
| topic | Enamel matrix Amelogenin Ameloblastin Enamelin Amelotin Odontogenic ameloblast-associated protein Apin |
| url | http://www.sciencedirect.com/science/article/pii/S1882761614000027 |
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