Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR
ABSTRACT Objective To evaluate the role of chest computed tomography in patients with COVID-19 who presented initial negative result in reverse transcriptase-polymerase chain reaction (RT-PCR). Methods A single-center, retrospective study that evaluated 39 patients with negative RT-PCR for COVID...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2021-11-01
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100245&tlng=pt |
| _version_ | 1828133775955984384 |
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| author | Eduardo Kaiser Ururahy Nunes Fonseca Lorena Carneiro Ferreira Bruna Melo Coelho Loureiro Daniel Giunchetti Strabelli Lucas de Pádua Gomes de Farias Gabriel Abrantes de Queiroz José Vitor Rassi Garcia Renato de Freitas Teixeira Victor Arcanjo Almeida Gama Rodrigo Caruso Chate Antonildes Nascimento Assunção Júnior Márcio Valente Yamada Sawamura Cesar Higa Nomura |
| author_facet | Eduardo Kaiser Ururahy Nunes Fonseca Lorena Carneiro Ferreira Bruna Melo Coelho Loureiro Daniel Giunchetti Strabelli Lucas de Pádua Gomes de Farias Gabriel Abrantes de Queiroz José Vitor Rassi Garcia Renato de Freitas Teixeira Victor Arcanjo Almeida Gama Rodrigo Caruso Chate Antonildes Nascimento Assunção Júnior Márcio Valente Yamada Sawamura Cesar Higa Nomura |
| author_sort | Eduardo Kaiser Ururahy Nunes Fonseca |
| collection | DOAJ |
| description | ABSTRACT Objective To evaluate the role of chest computed tomography in patients with COVID-19 who presented initial negative result in reverse transcriptase-polymerase chain reaction (RT-PCR). Methods A single-center, retrospective study that evaluated 39 patients with negative RT-PCR for COVID-19, who underwent chest computed tomography and had a final clinical or serological diagnosis of COVID-19. The visual tomographic classification was evaluated according to the Consensus of the Radiological Society of North America and software developed with artificial intelligence for automatic detection of findings and chance estimation of COVID-19. Results In the visual tomographic analysis, only one of them (3%) presented computed tomography classified as negative, 69% were classified as typical and 28% as indeterminate. In the evaluation using the software, only four (about 10%) had a probability of COVID-19 <25%. Conclusion Computed tomography can play an important role in management of suspected cases of COVID-19 with initial negative results in RT-PCR, especially considering those patients outside the ideal window for sample collection for RT-PCR. |
| first_indexed | 2024-04-11T17:24:18Z |
| format | Article |
| id | doaj.art-3291de9878e64f81814471c30b122574 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-11T17:24:18Z |
| publishDate | 2021-11-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-3291de9878e64f81814471c30b1225742022-12-22T04:12:24ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852021-11-011910.31744/einstein_journal/2021ao6363Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCREduardo Kaiser Ururahy Nunes Fonsecahttps://orcid.org/0000-0002-0233-0041Lorena Carneiro Ferreirahttps://orcid.org/0000-0003-3960-1375Bruna Melo Coelho Loureirohttps://orcid.org/0000-0002-7270-2664Daniel Giunchetti Strabellihttps://orcid.org/0000-0002-0526-5775Lucas de Pádua Gomes de Fariashttps://orcid.org/0000-0001-5195-9818Gabriel Abrantes de Queirozhttps://orcid.org/0000-0003-3391-6835José Vitor Rassi Garciahttps://orcid.org/0000-0001-5241-1651Renato de Freitas Teixeirahttps://orcid.org/0000-0001-6952-7247Victor Arcanjo Almeida Gamahttps://orcid.org/0000-0002-6666-2723Rodrigo Caruso Chatehttps://orcid.org/0000-0002-4193-7647Antonildes Nascimento Assunção Júniorhttps://orcid.org/0000-0002-3211-9650Márcio Valente Yamada Sawamurahttps://orcid.org/0000-0002-9424-9776Cesar Higa Nomurahttps://orcid.org/0000-0002-7131-6614ABSTRACT Objective To evaluate the role of chest computed tomography in patients with COVID-19 who presented initial negative result in reverse transcriptase-polymerase chain reaction (RT-PCR). Methods A single-center, retrospective study that evaluated 39 patients with negative RT-PCR for COVID-19, who underwent chest computed tomography and had a final clinical or serological diagnosis of COVID-19. The visual tomographic classification was evaluated according to the Consensus of the Radiological Society of North America and software developed with artificial intelligence for automatic detection of findings and chance estimation of COVID-19. Results In the visual tomographic analysis, only one of them (3%) presented computed tomography classified as negative, 69% were classified as typical and 28% as indeterminate. In the evaluation using the software, only four (about 10%) had a probability of COVID-19 <25%. Conclusion Computed tomography can play an important role in management of suspected cases of COVID-19 with initial negative results in RT-PCR, especially considering those patients outside the ideal window for sample collection for RT-PCR.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100245&tlng=ptCOVID-19CoronavirusCoronavirus infectionsPneumonia, viralTomography, X-ray computedReverse transcriptase polymerase chain reaction |
| spellingShingle | Eduardo Kaiser Ururahy Nunes Fonseca Lorena Carneiro Ferreira Bruna Melo Coelho Loureiro Daniel Giunchetti Strabelli Lucas de Pádua Gomes de Farias Gabriel Abrantes de Queiroz José Vitor Rassi Garcia Renato de Freitas Teixeira Victor Arcanjo Almeida Gama Rodrigo Caruso Chate Antonildes Nascimento Assunção Júnior Márcio Valente Yamada Sawamura Cesar Higa Nomura Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR Einstein (São Paulo) COVID-19 Coronavirus Coronavirus infections Pneumonia, viral Tomography, X-ray computed Reverse transcriptase polymerase chain reaction |
| title | Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR |
| title_full | Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR |
| title_fullStr | Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR |
| title_full_unstemmed | Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR |
| title_short | Chest computed tomography in the diagnosis of COVID-19 in patients with false negative RT-PCR |
| title_sort | chest computed tomography in the diagnosis of covid 19 in patients with false negative rt pcr |
| topic | COVID-19 Coronavirus Coronavirus infections Pneumonia, viral Tomography, X-ray computed Reverse transcriptase polymerase chain reaction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100245&tlng=pt |
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