Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope
Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus being potential candidates as antibacterial age...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-08-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/10/8/428 |
| _version_ | 1819211874354331648 |
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| author | Maria João Catalão Madalena Pimentel |
| author_facet | Maria João Catalão Madalena Pimentel |
| author_sort | Maria João Catalão |
| collection | DOAJ |
| description | Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus being potential candidates as antibacterial agents. These comprise lipolytic enzymes that target the mycolic acid-containing outer membrane and peptidoglycan hydrolases responsive to the atypical mycobacterial peptidoglycan layer. In the recent years, a remarkable progress has been made, particularly on the comprehension of the mechanisms of bacteriophage lysis proteins activity and regulation. Notwithstanding, information about mycobacteriophages lysis strategies is limited and is mainly represented by the studies performed with mycobacteriophage Ms6. Since mycobacteriophages target a specific group of bacteria, which include Mycobacterium tuberculosis responsible for one of the leading causes of death worldwide, exploitation of the use of these lytic enzymes demands a special attention, as they may be an alternative to tackle multidrug resistant tuberculosis. This review focuses on the current knowledge of the function of lysis proteins encoded by mycobacteriophages and their potential applications, which may contribute to increasing the effectiveness of antimycobacterial therapy. |
| first_indexed | 2024-12-23T06:34:00Z |
| format | Article |
| id | doaj.art-3292781e2dfb4ba2a67feefdd807d879 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-23T06:34:00Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3292781e2dfb4ba2a67feefdd807d8792022-12-21T17:56:51ZengMDPI AGViruses1999-49152018-08-0110842810.3390/v10080428v10080428Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell EnvelopeMaria João Catalão0Madalena Pimentel1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, PortugalResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, PortugalMycobacteriophages are viruses that specifically infect mycobacteria, which ultimately culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell envelope arrangement have been identified in mycobacteriophage genomes, thus being potential candidates as antibacterial agents. These comprise lipolytic enzymes that target the mycolic acid-containing outer membrane and peptidoglycan hydrolases responsive to the atypical mycobacterial peptidoglycan layer. In the recent years, a remarkable progress has been made, particularly on the comprehension of the mechanisms of bacteriophage lysis proteins activity and regulation. Notwithstanding, information about mycobacteriophages lysis strategies is limited and is mainly represented by the studies performed with mycobacteriophage Ms6. Since mycobacteriophages target a specific group of bacteria, which include Mycobacterium tuberculosis responsible for one of the leading causes of death worldwide, exploitation of the use of these lytic enzymes demands a special attention, as they may be an alternative to tackle multidrug resistant tuberculosis. This review focuses on the current knowledge of the function of lysis proteins encoded by mycobacteriophages and their potential applications, which may contribute to increasing the effectiveness of antimycobacterial therapy.http://www.mdpi.com/1999-4915/10/8/428mycobacteriophagesMs6endolysinsLysBlysismycobacteria |
| spellingShingle | Maria João Catalão Madalena Pimentel Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope Viruses mycobacteriophages Ms6 endolysins LysB lysis mycobacteria |
| title | Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope |
| title_full | Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope |
| title_fullStr | Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope |
| title_full_unstemmed | Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope |
| title_short | Mycobacteriophage Lysis Enzymes: Targeting the Mycobacterial Cell Envelope |
| title_sort | mycobacteriophage lysis enzymes targeting the mycobacterial cell envelope |
| topic | mycobacteriophages Ms6 endolysins LysB lysis mycobacteria |
| url | http://www.mdpi.com/1999-4915/10/8/428 |
| work_keys_str_mv | AT mariajoaocatalao mycobacteriophagelysisenzymestargetingthemycobacterialcellenvelope AT madalenapimentel mycobacteriophagelysisenzymestargetingthemycobacterialcellenvelope |