New insights into the genetic mechanism of IQ in Autism Spectrum Disorders

New insights into the genetic mechanism of IQ in Autism Spectrum Disorders

Autism spectrum disorders (ASD) is a complex condition with a number of underlying subtypes with different symptoms and presumably different genetic causes. One important difference between these sub-phenotypes is cognition. Some forms of ASD such as Asperger’s keep cognitive development intact whil...

Full description

Bibliographic Details
Main Authors:	Harold Zhaokun Wang, Hai-De eQin, Wei eGuo, Jack eSamuels, Yin Y Shugart
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-10-01
Series:	Frontiers in Genetics
Subjects:	autism GWAS cognitive development rare variants Pedigree based functional variants
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00195/full

Similar Items

Weighted pedigree-based statistics for testing the association of rare variants
by: Shugart Yin Yao, et al.
Published: (2012-11-01)

Comprehensive Analysis of Rare Variants of 101 Autism-Linked Genes in a Hungarian Cohort of Autism Spectrum Disorder Patients
by: Péter Balicza, et al.
Published: (2019-05-01)

Alternatives to Gold Standard Diagnostic Tools for Distinguishing “Natural Kinds” on the Autism Spectrum
by: Anne Philippe
Published: (2022-06-01)

Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses
by: Bàrbara Torrico, et al.
Published: (2020-06-01)

Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data
by: Jaleal S. Sanjak, et al.
Published: (2016-04-01)

The Relevance of Variants With Unknown Significance for Autism Spectrum Disorder Considering the Genotype–Phenotype Interrelationship
by: Diogo V. Lovato, et al.
Published: (2019-06-01)

Spectrum of genetic disorders and gene variants in the United Arab Emirates national population: insights from the CTGA database
by: Sami Bizzari, et al.
Published: (2023-05-01)

Whole Exome Sequencing Identifies a Novel Predisposing Gene, MAPKAP1, for Familial Mixed Mood Disorder
by: Chunxia Yang, et al.
Published: (2019-02-01)

Shared and divergent contribution of vitamin A and oxytocin to the aetiology of autism spectrum disorder
by: Tao Wang, et al.
Published: (2023-01-01)

Genetic Risk Factors and Clinical Outcomes in Childhood Eye Cancers: A Review
by: Syed Hameed, et al.
Published: (2024-02-01)

Searching for solutions to the missing heritability problem
by: Luisa F Pallares
Published: (2019-12-01)

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia
by: Kanako Ishizuka, et al.
Published: (2020-09-01)

Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools
by: Sanjeev Sariya, et al.
Published: (2019-04-01)

Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder
by: Behrang Mahjani, et al.
Published: (2021-10-01)

Multiple Genetic Rare Variants in Autism Spectrum Disorders: A Single-Center Targeted NGS Study
by: Chiara Reale, et al.
Published: (2021-08-01)

Common Genetic Variants Found in HLA and KIR Immune Genes in Autism Spectrum Disorder
by: Anthony R Torres, et al.
Published: (2016-10-01)

Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis
by: Chiara Scapoli, et al.
Published: (2021-12-01)

Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population
by: Robert W. Read, et al.
Published: (2021-03-01)

The Emerging Genetic Landscape of Hirschsprung Disease and Its Potential Clinical Applications
by: Anwarul Karim, et al.
Published: (2021-08-01)

Sequencing-based genome-wide association studies reporting standards
by: Aoife McMahon, et al.
Published: (2021-10-01)

Functional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder
by: Lin Wang, et al.
Published: (2020-10-01)

Commentary: Autism: A model of neurodevelopmental diversity informed by genomics
by: Darko Sarovic, et al.
Published: (2023-01-01)

Molecular Analysis of Neuronal Cell Surface Protein gene; Neuroligin 3 in Autism Spectrum Disorder
by: Rajat Hegde, et al.
Published: (2020-01-01)

Impact of on-site clinical genetics consultations on diagnostic rate in children and young adults with autism spectrum disorder
by: Arnold Munnich, et al.
Published: (2019-08-01)

Gene Variants Involved in Nonsense-Mediated mRNA Decay Suggest a Role in Autism Spectrum Disorder
by: Ana Rita Marques, et al.
Published: (2022-03-01)

Statistical Dissection of the Genetic Determinants of Phenotypic Heterogeneity in Genes with Multiple Associated Rare Diseases
by: Tatyana E. Lazareva, et al.
Published: (2023-11-01)

Identification and Characterization of Two Novel Compounds: Heterozygous Variants of Lipoprotein Lipase in Two Pedigrees With Type I Hyperlipoproteinemia
by: Shuping Wang, et al.
Published: (2022-07-01)

Identification of Neurotransmission and Synaptic Biological Processes Disrupted in Autism Spectrum Disorder Using Interaction Networks and Community Detection Analysis
by: Joana Vilela, et al.
Published: (2023-11-01)

Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants
by: Karen Y. He, et al.
Published: (2023-11-01)

PCOS-GWAS Susceptibility Variants in THADA, INSR, TOX3, and DENND1A Are Associated With Metabolic Syndrome or Insulin Resistance in Women With PCOS
by: Ye Tian, et al.
Published: (2020-04-01)

Next Generation Sequencing of 134 Children with Autism Spectrum Disorder and Regression
by: Jiani Yin, et al.
Published: (2020-07-01)

Disease causing property analyzation of variants in 12 Chinese families with polycystic kidney disease
by: Kexian Dong, et al.
Published: (2020-11-01)

A new conceptual framework for investigating complex genetic disease
by: Shobbir eHussain
Published: (2015-11-01)

Support for calcium channel gene defects in autism spectrum disorders
by: Lu Ake Tzu-Hui, et al.
Published: (2012-12-01)

A Rare Confusing Nevus Variant: Meyerson Nevus
by: Pelin YILDIZ, et al.
Published: (2018-01-01)

Somatic Mosaicism and Autism Spectrum Disorder
by: Alissa M. D’Gama
Published: (2021-10-01)

Integrative analysis of functional genomic annotations and sequencing data to identify rare causal variants via hierarchical modeling
by: Marinela eCapanu, et al.
Published: (2015-05-01)

Autism Spectrum Disorder and IQ – A Complex Interplay
by: Nicole Wolff, et al.
Published: (2022-04-01)

Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients
by: Melania Lippi, et al.
Published: (2022-07-01)

Targeted Sequencing of 242 Clinically Important Genes in the Russian Population From the Ivanovo Region
by: Vasily E. Ramensky, et al.
Published: (2021-10-01)