Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review
Abstract Acute kidney injury (AKI) is a common and serious complication of cardiac surgery and is associated with increased mortality and morbidity, accompanied by a substantial economic burden. The pathogenesis of cardiac surgery-associated acute kidney injury (CSA-AKI) is multifactorial and comple...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-00990-2 |
| _version_ | 1811175927856496640 |
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| author | Ying Yu Chenning Li Shuainan Zhu Lin Jin Yan Hu Xiaomin Ling Changhong Miao Kefang Guo |
| author_facet | Ying Yu Chenning Li Shuainan Zhu Lin Jin Yan Hu Xiaomin Ling Changhong Miao Kefang Guo |
| author_sort | Ying Yu |
| collection | DOAJ |
| description | Abstract Acute kidney injury (AKI) is a common and serious complication of cardiac surgery and is associated with increased mortality and morbidity, accompanied by a substantial economic burden. The pathogenesis of cardiac surgery-associated acute kidney injury (CSA-AKI) is multifactorial and complex, with a variety of pathophysiological theories. In addition to the existing diagnostic criteria, the exploration and validation of biomarkers is the focus of research in the field of CSA-AKI diagnosis. Prevention remains the key to the management of CSA-AKI, and common strategies include maintenance of renal perfusion, individualized blood pressure targets, balanced fluid management, goal-directed oxygen delivery, and avoidance of nephrotoxins. This article reviews the pathogenesis, definition and diagnosis, and pharmacological and nonpharmacological prevention strategies of AKI in cardiac surgical patients. |
| first_indexed | 2024-04-10T19:43:54Z |
| format | Article |
| id | doaj.art-3296126251fa4858a34846e252a5c91e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-10T19:43:54Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-3296126251fa4858a34846e252a5c91e2023-01-29T12:07:35ZengBMCEuropean Journal of Medical Research2047-783X2023-01-0128111810.1186/s40001-023-00990-2Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative reviewYing Yu0Chenning Li1Shuainan Zhu2Lin Jin3Yan Hu4Xiaomin Ling5Changhong Miao6Kefang Guo7Department of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anaesthesiology, Zhongshan Hospital, Fudan UniversityAbstract Acute kidney injury (AKI) is a common and serious complication of cardiac surgery and is associated with increased mortality and morbidity, accompanied by a substantial economic burden. The pathogenesis of cardiac surgery-associated acute kidney injury (CSA-AKI) is multifactorial and complex, with a variety of pathophysiological theories. In addition to the existing diagnostic criteria, the exploration and validation of biomarkers is the focus of research in the field of CSA-AKI diagnosis. Prevention remains the key to the management of CSA-AKI, and common strategies include maintenance of renal perfusion, individualized blood pressure targets, balanced fluid management, goal-directed oxygen delivery, and avoidance of nephrotoxins. This article reviews the pathogenesis, definition and diagnosis, and pharmacological and nonpharmacological prevention strategies of AKI in cardiac surgical patients.https://doi.org/10.1186/s40001-023-00990-2Acute kidney injuryCardiac surgeryDiagnosisPathophysiologyPathogenesisPrevention |
| spellingShingle | Ying Yu Chenning Li Shuainan Zhu Lin Jin Yan Hu Xiaomin Ling Changhong Miao Kefang Guo Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review European Journal of Medical Research Acute kidney injury Cardiac surgery Diagnosis Pathophysiology Pathogenesis Prevention |
| title | Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review |
| title_full | Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review |
| title_fullStr | Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review |
| title_full_unstemmed | Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review |
| title_short | Diagnosis, pathophysiology and preventive strategies for cardiac surgery-associated acute kidney injury: a narrative review |
| title_sort | diagnosis pathophysiology and preventive strategies for cardiac surgery associated acute kidney injury a narrative review |
| topic | Acute kidney injury Cardiac surgery Diagnosis Pathophysiology Pathogenesis Prevention |
| url | https://doi.org/10.1186/s40001-023-00990-2 |
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