Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus
Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregna...
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| Format: | Article |
| Language: | English |
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Instituto Materno Infantil de Pernambuco
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| Series: | Revista Brasileira de Saúde Materno Infantil |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400833&lng=en&tlng=en |
| _version_ | 1818433934680129536 |
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| author | Vanessa Marcon de Oliveira Ernesto Antonio Figueiró-Filho Cristiane Munaretto Ferreira Erica Freire de Vasconcelos Pereira |
| author_facet | Vanessa Marcon de Oliveira Ernesto Antonio Figueiró-Filho Cristiane Munaretto Ferreira Erica Freire de Vasconcelos Pereira |
| author_sort | Vanessa Marcon de Oliveira |
| collection | DOAJ |
| description | Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p<0.05). The relative risks for antiphospholipid antibodies were 13.20 (ICR95%= 1.81 - 96.46) in pregnant women with SLE, 7.26 (CI95%= 1.77 - 29.86) for the presence of serum markers of hereditary thrombophilia and 7.92 (CI95%= 2.62 - 3.94) for the presence of hereditary thrombophilia and/or antiphospholipid antibodies. Conclusions: the identification of markers for hereditary and/or acquired thrombophilia in pregnant women with lupus may be clinically useful to determine which patients have a higher risk of obstetric complications. |
| first_indexed | 2024-12-14T16:28:59Z |
| format | Article |
| id | doaj.art-3296887417874660bf05b6fe27f8fce6 |
| institution | Directory Open Access Journal |
| issn | 1806-9304 |
| language | English |
| last_indexed | 2024-12-14T16:28:59Z |
| publisher | Instituto Materno Infantil de Pernambuco |
| record_format | Article |
| series | Revista Brasileira de Saúde Materno Infantil |
| spelling | doaj.art-3296887417874660bf05b6fe27f8fce62022-12-21T22:54:37ZengInstituto Materno Infantil de PernambucoRevista Brasileira de Saúde Materno Infantil1806-930417483384210.1590/1806-93042017000400012S1519-38292017000400833Serum markers thrombophilia in pregnant women with Systemic Lupus ErythematosusVanessa Marcon de OliveiraErnesto Antonio Figueiró-FilhoCristiane Munaretto FerreiraErica Freire de Vasconcelos PereiraAbstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p<0.05). The relative risks for antiphospholipid antibodies were 13.20 (ICR95%= 1.81 - 96.46) in pregnant women with SLE, 7.26 (CI95%= 1.77 - 29.86) for the presence of serum markers of hereditary thrombophilia and 7.92 (CI95%= 2.62 - 3.94) for the presence of hereditary thrombophilia and/or antiphospholipid antibodies. Conclusions: the identification of markers for hereditary and/or acquired thrombophilia in pregnant women with lupus may be clinically useful to determine which patients have a higher risk of obstetric complications.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400833&lng=en&tlng=enSystemic lupus erythematosusThrombophiliaAntiphospholipid syndromePregnancy complicationshematologic |
| spellingShingle | Vanessa Marcon de Oliveira Ernesto Antonio Figueiró-Filho Cristiane Munaretto Ferreira Erica Freire de Vasconcelos Pereira Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus Revista Brasileira de Saúde Materno Infantil Systemic lupus erythematosus Thrombophilia Antiphospholipid syndrome Pregnancy complications hematologic |
| title | Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus |
| title_full | Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus |
| title_fullStr | Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus |
| title_full_unstemmed | Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus |
| title_short | Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus |
| title_sort | serum markers thrombophilia in pregnant women with systemic lupus erythematosus |
| topic | Systemic lupus erythematosus Thrombophilia Antiphospholipid syndrome Pregnancy complications hematologic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400833&lng=en&tlng=en |
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