Developing In Situ Chemometric Models with Raman Spectroscopy for Monitoring an API Disproportionation with a Complex Polymorphic Landscape

Developing In Situ Chemometric Models with Raman Spectroscopy for Monitoring an API Disproportionation with a Complex Polymorphic Landscape

An in situ Raman method was developed to characterize the disproportionation of two salts involving a complex polymorphic landscape comprising up to two metastable and one stable freebase forms. Few precedents exist for Raman calibration procedures for solid form quantitation involving more than two...

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Bibliographic Details
Main Authors:	Shikhar Mohan, Yi Li, Kevin Chu, Bing Shi, Liliana De La Paz, Prarthana Bakre, Chris Foti, Victor Rucker, Chiajen Lai
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Pharmaceuticals
Subjects:	Raman spectroscopy X-ray diffraction process analytical technology process monitoring salt disproportionation
Online Access:	https://www.mdpi.com/1424-8247/16/2/327

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