Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis
Abstract Background Leptin has been shown to have various physiological and pathological roles in the canine gallbladder. In this study, we performed pre- and postoperative short-term follow-up analyses to confirm changes in serum leptin levels before and after cholecystectomy due to gallbladder muc...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-06-01
|
| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12917-019-1964-z |
| _version_ | 1818279793183948800 |
|---|---|
| author | Sungin Lee Aeri Lee Oh-kyeong Kweon Wan Hee Kim |
| author_facet | Sungin Lee Aeri Lee Oh-kyeong Kweon Wan Hee Kim |
| author_sort | Sungin Lee |
| collection | DOAJ |
| description | Abstract Background Leptin has been shown to have various physiological and pathological roles in the canine gallbladder. In this study, we performed pre- and postoperative short-term follow-up analyses to confirm changes in serum leptin levels before and after cholecystectomy due to gallbladder mucocele (GBM) or cholelithiasis in dogs. Results Twenty-six cholecystectomized dogs (GBM: n = 14; cholelithiasis: n = 12) for prophylactic or clinical symptom relief were enrolled in the present study. Dogs were subgrouped according to clinical symptoms and prognosis after surgery as follows: 1) asymptomatic group (n = 13), 2) recovery group (n = 8), and 3) death group (n = 5). Liver enzymes, total bilirubin, lipid profiles, and leptin concentrations were determined from sera on the pre-operative day and at 1, 3, and 7 days postoperation. Serum leptin concentrations were gradually but significantly decreased in the asymptomatic group (p = 0.008, 0.004, and 0.004 on days 1, 3, and 7, respectively, compared with that before surgery) and the recovery group (p = 0.048 and 0.048 on days 3 and 7, respectively, compared with that before surgery). However, in the death group, leptin concentrations did not differ significantly over time (p = 0.564). Additionally, serum leptin levels in the recovery group (p = 0.006) and death group (p = 0.021) were significantly higher than those in the asymptomatic group. Liver enzymes and total bilirubin (T-Bil) were significantly decreased only in the recovery group, particularly on day 7. In the asymptomatic group, liver enzymes and T-Bil were not changed significantly over time, and in the death group, only T-Bil was significantly decreased on day 7. Total cholesterol and triglyceride levels were not significantly decreased over time in all groups. Conclusions These results indicate that leptin is a potential biomarker reflecting the severity and prognosis of GBM and cholelithiasis both before and after cholecystectomy in dogs. |
| first_indexed | 2024-12-12T23:38:58Z |
| format | Article |
| id | doaj.art-3298448f6ce54f9898813b447a70725f |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-12T23:38:58Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-3298448f6ce54f9898813b447a70725f2022-12-22T00:07:16ZengBMCBMC Veterinary Research1746-61482019-06-011511910.1186/s12917-019-1964-zChanges in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasisSungin Lee0Aeri Lee1Oh-kyeong Kweon2Wan Hee Kim3Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National UniversityDepartment of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National UniversityDepartment of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National UniversityDepartment of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National UniversityAbstract Background Leptin has been shown to have various physiological and pathological roles in the canine gallbladder. In this study, we performed pre- and postoperative short-term follow-up analyses to confirm changes in serum leptin levels before and after cholecystectomy due to gallbladder mucocele (GBM) or cholelithiasis in dogs. Results Twenty-six cholecystectomized dogs (GBM: n = 14; cholelithiasis: n = 12) for prophylactic or clinical symptom relief were enrolled in the present study. Dogs were subgrouped according to clinical symptoms and prognosis after surgery as follows: 1) asymptomatic group (n = 13), 2) recovery group (n = 8), and 3) death group (n = 5). Liver enzymes, total bilirubin, lipid profiles, and leptin concentrations were determined from sera on the pre-operative day and at 1, 3, and 7 days postoperation. Serum leptin concentrations were gradually but significantly decreased in the asymptomatic group (p = 0.008, 0.004, and 0.004 on days 1, 3, and 7, respectively, compared with that before surgery) and the recovery group (p = 0.048 and 0.048 on days 3 and 7, respectively, compared with that before surgery). However, in the death group, leptin concentrations did not differ significantly over time (p = 0.564). Additionally, serum leptin levels in the recovery group (p = 0.006) and death group (p = 0.021) were significantly higher than those in the asymptomatic group. Liver enzymes and total bilirubin (T-Bil) were significantly decreased only in the recovery group, particularly on day 7. In the asymptomatic group, liver enzymes and T-Bil were not changed significantly over time, and in the death group, only T-Bil was significantly decreased on day 7. Total cholesterol and triglyceride levels were not significantly decreased over time in all groups. Conclusions These results indicate that leptin is a potential biomarker reflecting the severity and prognosis of GBM and cholelithiasis both before and after cholecystectomy in dogs.http://link.springer.com/article/10.1186/s12917-019-1964-zCanineCholecystectomyCholelithiasisGallbladder mucoceleLeptin |
| spellingShingle | Sungin Lee Aeri Lee Oh-kyeong Kweon Wan Hee Kim Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis BMC Veterinary Research Canine Cholecystectomy Cholelithiasis Gallbladder mucocele Leptin |
| title | Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis |
| title_full | Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis |
| title_fullStr | Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis |
| title_full_unstemmed | Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis |
| title_short | Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis |
| title_sort | changes in pre and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis |
| topic | Canine Cholecystectomy Cholelithiasis Gallbladder mucocele Leptin |
| url | http://link.springer.com/article/10.1186/s12917-019-1964-z |
| work_keys_str_mv | AT sunginlee changesinpreandpostoperativeserumleptinconcentrationsindogswithgallbladdermucoceleandcholelithiasis AT aerilee changesinpreandpostoperativeserumleptinconcentrationsindogswithgallbladdermucoceleandcholelithiasis AT ohkyeongkweon changesinpreandpostoperativeserumleptinconcentrationsindogswithgallbladdermucoceleandcholelithiasis AT wanheekim changesinpreandpostoperativeserumleptinconcentrationsindogswithgallbladdermucoceleandcholelithiasis |