Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective
Polyhydroxyalkanoates (PHA) have attracted interest as bio-based, biodegradable biocompatible polymers. Researchers have accumulated a wide breadth of knowledge on the biosynthetic processes of these valuable polymers, with experts in the disciplines of microbiology, biochemistry, physics, medicine,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Siberian Federal University
2012-09-01
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| Series: | Журнал Сибирского федерального университета: Серия Биология |
| Subjects: | |
| Online Access: | http://elib.sfu-kras.ru/bitstream/2311/3159/1/01_Brigham.pdf |
| _version_ | 1818261232057057280 |
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| author | Christopher J. Brigham Anthony J. Sinskey |
| author_facet | Christopher J. Brigham Anthony J. Sinskey |
| author_sort | Christopher J. Brigham |
| collection | DOAJ |
| description | Polyhydroxyalkanoates (PHA) have attracted interest as bio-based, biodegradable biocompatible polymers. Researchers have accumulated a wide breadth of knowledge on the biosynthetic processes of these valuable polymers, with experts in the disciplines of microbiology, biochemistry, physics, medicine, and engineering contributing to the current state of knowledge of synthesis, production and application of PHA. An important perspective of PHA biosynthesis is the subset of microbial enzymes that are involved in producing this polymer and their many permutations. In this review, we survey the key enzymes involved in synthesis and homeostasis of all types of PHA. Emphasis is made on structure and function of enzymes and how enzymology has shaped knowledge of the PHA production pathway and ushered in new discoveries. |
| first_indexed | 2024-12-12T18:43:57Z |
| format | Article |
| id | doaj.art-329af4a666ca4785bf289037ace65883 |
| institution | Directory Open Access Journal |
| issn | 1997-1389 2313-5530 |
| language | English |
| last_indexed | 2024-12-12T18:43:57Z |
| publishDate | 2012-09-01 |
| publisher | Siberian Federal University |
| record_format | Article |
| series | Журнал Сибирского федерального университета: Серия Биология |
| spelling | doaj.art-329af4a666ca4785bf289037ace658832022-12-22T00:15:35ZengSiberian Federal UniversityЖурнал Сибирского федерального университета: Серия Биология1997-13892313-55302012-09-0153220242http://elib.sfu-kras.ru/handle/2311/3159Polyhydroxyalkanoate Production Enzymes: a Survey and Biological PerspectiveChristopher J. Brigham0Anthony J. Sinskey1Department of Biology, Massachusetts Institute of Technology , Cambridge, MA 02139, USASiberian Federal University Engineering Systems Division, Massachusetts Institute of Technology Division of Health Sciences Technology, Massachusetts Institute of Technology Department of Biology, Massachusetts Institute of Technology , 79 Svobodny, Krasnoyarsk, 660041 Russia Cambridge, MA 02139, USA Cambridge, MA 02139, USA Cambridge, MA 02139, USAPolyhydroxyalkanoates (PHA) have attracted interest as bio-based, biodegradable biocompatible polymers. Researchers have accumulated a wide breadth of knowledge on the biosynthetic processes of these valuable polymers, with experts in the disciplines of microbiology, biochemistry, physics, medicine, and engineering contributing to the current state of knowledge of synthesis, production and application of PHA. An important perspective of PHA biosynthesis is the subset of microbial enzymes that are involved in producing this polymer and their many permutations. In this review, we survey the key enzymes involved in synthesis and homeostasis of all types of PHA. Emphasis is made on structure and function of enzymes and how enzymology has shaped knowledge of the PHA production pathway and ushered in new discoveries.http://elib.sfu-kras.ru/bitstream/2311/3159/1/01_Brigham.pdfbioplasticspolyhydroxyalkanoateenzymesgranule associated proteinspolymer biosynthesisPHA homeostasis |
| spellingShingle | Christopher J. Brigham Anthony J. Sinskey Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective Журнал Сибирского федерального университета: Серия Биология bioplastics polyhydroxyalkanoate enzymes granule associated proteins polymer biosynthesis PHA homeostasis |
| title | Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective |
| title_full | Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective |
| title_fullStr | Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective |
| title_full_unstemmed | Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective |
| title_short | Polyhydroxyalkanoate Production Enzymes: a Survey and Biological Perspective |
| title_sort | polyhydroxyalkanoate production enzymes a survey and biological perspective |
| topic | bioplastics polyhydroxyalkanoate enzymes granule associated proteins polymer biosynthesis PHA homeostasis |
| url | http://elib.sfu-kras.ru/bitstream/2311/3159/1/01_Brigham.pdf |
| work_keys_str_mv | AT christopherjbrigham polyhydroxyalkanoateproductionenzymesasurveyandbiologicalperspective AT anthonyjsinskey polyhydroxyalkanoateproductionenzymesasurveyandbiologicalperspective |