Behavioral Alterations in Mice Carrying Homozygous HDAC4A778T Missense Mutation Associated With Eating Disorder

Behavioral Alterations in Mice Carrying Homozygous HDAC4A778T Missense Mutation Associated With Eating Disorder

Eating disorders (EDs) are serious mental illnesses thought to arise from the complex gene-environment interactions. DNA methylation patterns in histone deacetylase 4 (HDAC4) locus have been associated with EDs and we have previously identified a missense mutation in the HDAC4 gene (HDAC4A786T) that...

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Bibliographic Details
Main Authors: Kevin C. Davis, Kenji Saito, Samuel R. Rodeghiero, Brandon A. Toth, Michael Lutter, Huxing Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Neuroscience
Subjects:
eating disorders
histone deacetylase 4
mouse behaviors
social subordination
body weight
food intake
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00139/full

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