Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures th...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3249 |
| _version_ | 1797620589140115456 |
|---|---|
| author | Daniel Arcos María Teresa Portolés |
| author_facet | Daniel Arcos María Teresa Portolés |
| author_sort | Daniel Arcos |
| collection | DOAJ |
| description | Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date. |
| first_indexed | 2024-03-11T08:43:45Z |
| format | Article |
| id | doaj.art-329bbfe3a2804214b3eea7eaae4e0703 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:43:45Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-329bbfe3a2804214b3eea7eaae4e07032023-11-16T20:57:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244324910.3390/ijms24043249Mesoporous Bioactive Nanoparticles for Bone Tissue ApplicationsDaniel Arcos0María Teresa Portolés1Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainCIBER de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, ISCIII, 28040 Madrid, SpainResearch in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.https://www.mdpi.com/1422-0067/24/4/3249mesoporous nanoparticlesbioactivitybone regenerationdrug deliverytherapeutic ionscellular response |
| spellingShingle | Daniel Arcos María Teresa Portolés Mesoporous Bioactive Nanoparticles for Bone Tissue Applications International Journal of Molecular Sciences mesoporous nanoparticles bioactivity bone regeneration drug delivery therapeutic ions cellular response |
| title | Mesoporous Bioactive Nanoparticles for Bone Tissue Applications |
| title_full | Mesoporous Bioactive Nanoparticles for Bone Tissue Applications |
| title_fullStr | Mesoporous Bioactive Nanoparticles for Bone Tissue Applications |
| title_full_unstemmed | Mesoporous Bioactive Nanoparticles for Bone Tissue Applications |
| title_short | Mesoporous Bioactive Nanoparticles for Bone Tissue Applications |
| title_sort | mesoporous bioactive nanoparticles for bone tissue applications |
| topic | mesoporous nanoparticles bioactivity bone regeneration drug delivery therapeutic ions cellular response |
| url | https://www.mdpi.com/1422-0067/24/4/3249 |
| work_keys_str_mv | AT danielarcos mesoporousbioactivenanoparticlesforbonetissueapplications AT mariateresaportoles mesoporousbioactivenanoparticlesforbonetissueapplications |