Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder
Hemophagocytic disorders are severe and life-threatening conditions that can be genetic in origin [i.e., primary hemophagocytic lymphohistiocytosis (HLH)] or result from infections (i.e., secondary hemophagocytic lymphohistiocytosis), rheumatologic disease [i.e., macrophage activation syndrome (MAS)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1023522/full |
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| author | Eliza I. Pope Hosanna Au Hosanna Au Deborah M. Levy Deborah M. Levy Ruud H. J. Verstegen Ruud H. J. Verstegen Ruud H. J. Verstegen |
| author_facet | Eliza I. Pope Hosanna Au Hosanna Au Deborah M. Levy Deborah M. Levy Ruud H. J. Verstegen Ruud H. J. Verstegen Ruud H. J. Verstegen |
| author_sort | Eliza I. Pope |
| collection | DOAJ |
| description | Hemophagocytic disorders are severe and life-threatening conditions that can be genetic in origin [i.e., primary hemophagocytic lymphohistiocytosis (HLH)] or result from infections (i.e., secondary hemophagocytic lymphohistiocytosis), rheumatologic disease [i.e., macrophage activation syndrome (MAS)], and less frequently immunodeficiency or metabolic disease. Although rare, drug-induced hemophagocytosis needs to be considered in the work-up as it requires specific management strategies. Most drug-induced hemophagocytic disorders are related to Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). We present the case of a 7-year-old girl who initially presented with fever, maculopapular rash, and unilateral lymphadenopathy, who went on to develop hemophagocytosis secondary to DRESS caused by prolonged combination treatment with amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole. This case illustrates the importance of considering adverse drug reactions in the evaluations of patients with a hemophagocytic process. |
| first_indexed | 2024-04-12T10:43:20Z |
| format | Article |
| id | doaj.art-329ce36335e846ebbc3025a0591cf27d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T10:43:20Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-329ce36335e846ebbc3025a0591cf27d2022-12-22T03:36:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-11-011310.3389/fphar.2022.10235221023522Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorderEliza I. Pope0Hosanna Au1Hosanna Au2Deborah M. Levy3Deborah M. Levy4Ruud H. J. Verstegen5Ruud H. J. Verstegen6Ruud H. J. Verstegen7Department of Paediatrics, University of Toronto, Toronto, ON, CanadaDepartment of Paediatrics, University of Toronto, Toronto, ON, CanadaDivision of Paediatric Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Paediatrics, University of Toronto, Toronto, ON, CanadaDivision of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Paediatrics, University of Toronto, Toronto, ON, CanadaDivision of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, CanadaDivision of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, CanadaHemophagocytic disorders are severe and life-threatening conditions that can be genetic in origin [i.e., primary hemophagocytic lymphohistiocytosis (HLH)] or result from infections (i.e., secondary hemophagocytic lymphohistiocytosis), rheumatologic disease [i.e., macrophage activation syndrome (MAS)], and less frequently immunodeficiency or metabolic disease. Although rare, drug-induced hemophagocytosis needs to be considered in the work-up as it requires specific management strategies. Most drug-induced hemophagocytic disorders are related to Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). We present the case of a 7-year-old girl who initially presented with fever, maculopapular rash, and unilateral lymphadenopathy, who went on to develop hemophagocytosis secondary to DRESS caused by prolonged combination treatment with amoxicillin/clavulanic acid and trimethoprim/sulfamethoxazole. This case illustrates the importance of considering adverse drug reactions in the evaluations of patients with a hemophagocytic process.https://www.frontiersin.org/articles/10.3389/fphar.2022.1023522/fullDRESS (drug reaction with eosinophilia and systemic symptoms)antibioticsdrug reactionhemophagocytosispediatricscase report |
| spellingShingle | Eliza I. Pope Hosanna Au Hosanna Au Deborah M. Levy Deborah M. Levy Ruud H. J. Verstegen Ruud H. J. Verstegen Ruud H. J. Verstegen Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder Frontiers in Pharmacology DRESS (drug reaction with eosinophilia and systemic symptoms) antibiotics drug reaction hemophagocytosis pediatrics case report |
| title | Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder |
| title_full | Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder |
| title_fullStr | Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder |
| title_full_unstemmed | Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder |
| title_short | Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS)-induced hemophagocytic disorder |
| title_sort | case report drug reaction with eosinophilia and systemic symptoms dress induced hemophagocytic disorder |
| topic | DRESS (drug reaction with eosinophilia and systemic symptoms) antibiotics drug reaction hemophagocytosis pediatrics case report |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1023522/full |
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