Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study
Objectives: This study aimed to investigate the effects of bevacizumab (an anti-VEGF antibody) on the structure of retina such as the thickness of the nerve fiber layer and macula with optical coherence tomography (OCT) in retinopathy of prematurity (ROP) patients. Materials and Methods: This cross-...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Aras Part Medical International Press
2023-10-01
|
| Series: | Crescent Journal of Medical and Biological Sciences |
| Subjects: | |
| Online Access: | http://www.cjmb.org/pdf.php?id=615 |
| _version_ | 1797682586322993152 |
|---|---|
| author | Amir Eftekhari Milani Bahareh Javani Mohamadhosein Ahoor Mehdi Abdi Shahshahani Fereshteh Farhadi |
| author_facet | Amir Eftekhari Milani Bahareh Javani Mohamadhosein Ahoor Mehdi Abdi Shahshahani Fereshteh Farhadi |
| author_sort | Amir Eftekhari Milani |
| collection | DOAJ |
| description | Objectives: This study aimed to investigate the effects of bevacizumab (an anti-VEGF antibody) on the structure of retina such as the thickness of the nerve fiber layer and macula with optical coherence tomography (OCT) in retinopathy of prematurity (ROP) patients. Materials and Methods: This cross-sectional study was conducted in 2021-2022 in Tabriz, Iran to investigate preterm children aged 4-6 years. To this end, a total of 300 eyes of 150 children were assigned to three groups and then were examined by performing Fundus examination of retina, eye refraction test, and OCT imaging. The first group included 100 eyes with a history of ROP and treated with bevacizumab, the second group consisted of 100 eyes with a history of ROP but improved spontaneously, and the third group comprised 100 eyes of preterm children without a history of ROP. Results: Foveal thickness was 235.46 ± 11 µm in the group receiving bevacizumab, 267.70 ± 12 µm in the group with spontaneous improvement of ROP, and 269.48 ± 10 µm in the group with no ROP. Therefore, the mean thickness of the fovea in the group receiving bevacizumab was significantly lower than that in the other two groups. In the group receiving bevacizumab, moreover, the thickness of the nerve layer of the retina was less than that in the other two groups (P<0.005). Conclusions: In sum, a greater understanding of the development of premature fovea was achieved, which may have facilitated identifying the possible clinical and long-term effects of these abnormal changes on adulthood visual acuity. It was recommended that further studies should be carried out to compare laser-treated eyes in order for expanding the scientific understanding of the development of premature fovea and other aspects of ROP, which may have decreased the preventable blindness rate. |
| first_indexed | 2024-03-12T00:01:56Z |
| format | Article |
| id | doaj.art-329d0efd88bd4fcfb55aa959ddd9e804 |
| institution | Directory Open Access Journal |
| issn | 2148-9696 |
| language | English |
| last_indexed | 2024-03-12T00:01:56Z |
| publishDate | 2023-10-01 |
| publisher | Aras Part Medical International Press |
| record_format | Article |
| series | Crescent Journal of Medical and Biological Sciences |
| spelling | doaj.art-329d0efd88bd4fcfb55aa959ddd9e8042023-09-17T11:12:40ZengAras Part Medical International PressCrescent Journal of Medical and Biological Sciences2148-96962023-10-0110416917510.34172/cjmb.2023.27CJMB-10087Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional StudyAmir Eftekhari Milani0Bahareh Javani1Mohamadhosein Ahoor2Mehdi Abdi Shahshahani3Fereshteh Farhadi4Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.Objectives: This study aimed to investigate the effects of bevacizumab (an anti-VEGF antibody) on the structure of retina such as the thickness of the nerve fiber layer and macula with optical coherence tomography (OCT) in retinopathy of prematurity (ROP) patients. Materials and Methods: This cross-sectional study was conducted in 2021-2022 in Tabriz, Iran to investigate preterm children aged 4-6 years. To this end, a total of 300 eyes of 150 children were assigned to three groups and then were examined by performing Fundus examination of retina, eye refraction test, and OCT imaging. The first group included 100 eyes with a history of ROP and treated with bevacizumab, the second group consisted of 100 eyes with a history of ROP but improved spontaneously, and the third group comprised 100 eyes of preterm children without a history of ROP. Results: Foveal thickness was 235.46 ± 11 µm in the group receiving bevacizumab, 267.70 ± 12 µm in the group with spontaneous improvement of ROP, and 269.48 ± 10 µm in the group with no ROP. Therefore, the mean thickness of the fovea in the group receiving bevacizumab was significantly lower than that in the other two groups. In the group receiving bevacizumab, moreover, the thickness of the nerve layer of the retina was less than that in the other two groups (P<0.005). Conclusions: In sum, a greater understanding of the development of premature fovea was achieved, which may have facilitated identifying the possible clinical and long-term effects of these abnormal changes on adulthood visual acuity. It was recommended that further studies should be carried out to compare laser-treated eyes in order for expanding the scientific understanding of the development of premature fovea and other aspects of ROP, which may have decreased the preventable blindness rate.http://www.cjmb.org/pdf.php?id=615retinopathy of prematuritybevacizumabfoveal thicknessrnfl thickness |
| spellingShingle | Amir Eftekhari Milani Bahareh Javani Mohamadhosein Ahoor Mehdi Abdi Shahshahani Fereshteh Farhadi Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study Crescent Journal of Medical and Biological Sciences retinopathy of prematurity bevacizumab foveal thickness rnfl thickness |
| title | Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study |
| title_full | Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study |
| title_fullStr | Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study |
| title_full_unstemmed | Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study |
| title_short | Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study |
| title_sort | foveal and retinal nerve fiber layer thickness in children with a history of retinopathy of prematurity treated with bevacizumab a cross sectional study |
| topic | retinopathy of prematurity bevacizumab foveal thickness rnfl thickness |
| url | http://www.cjmb.org/pdf.php?id=615 |
| work_keys_str_mv | AT amireftekharimilani fovealandretinalnervefiberlayerthicknessinchildrenwithahistoryofretinopathyofprematuritytreatedwithbevacizumabacrosssectionalstudy AT baharehjavani fovealandretinalnervefiberlayerthicknessinchildrenwithahistoryofretinopathyofprematuritytreatedwithbevacizumabacrosssectionalstudy AT mohamadhoseinahoor fovealandretinalnervefiberlayerthicknessinchildrenwithahistoryofretinopathyofprematuritytreatedwithbevacizumabacrosssectionalstudy AT mehdiabdishahshahani fovealandretinalnervefiberlayerthicknessinchildrenwithahistoryofretinopathyofprematuritytreatedwithbevacizumabacrosssectionalstudy AT fereshtehfarhadi fovealandretinalnervefiberlayerthicknessinchildrenwithahistoryofretinopathyofprematuritytreatedwithbevacizumabacrosssectionalstudy |