BPA Alters Estrogen Receptor Expression in the Heart After Viral Infection Activating Cardiac Mast Cells and T Cells Leading to Perimyocarditis and Fibrosis

BPA Alters Estrogen Receptor Expression in the Heart After Viral Infection Activating Cardiac Mast Cells and T Cells Leading to Perimyocarditis and Fibrosis

Myocarditis is an inflammatory heart disease that leads to dilated cardiomyopathy (DCM) and heart failure. Sex hormones play an important role in the development of myocarditis with testosterone driving disease in males and estrogen being cardioprotective in females. The human population is widely e...

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Bibliographic Details
Main Authors: Katelyn Ann Bruno, Jessica Elizabeth Mathews, Alex Lingyun Yang, J. Augusto Frisancho, Ashley Jennie Scott, Henry David Greyner, Frank Anthony Molina, Merci Shekinah Greenaway, George Maxwell Cooper, Adriana Bucek, Andrea Carolina Morales-Lara, Anneliese Ruth Hill, Anna Alisa Mease, Damian Nicolas Di Florio, John Michael Sousou, Alexandria Christine Coronado, Allison Ray Stafford, DeLisa Fairweather
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Endocrinology
Subjects:
myocarditis
endocrine disruptor
bisphenol A
estrogen receptor
mast cells
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00598/full

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