Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve
Objectives: Our study aimed to demonstrate the influence of left ventricular (LV) diastolic dysfunction on the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR). Methods: One hundred vessels from 90 patients were retrospectively analyzed. All...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1724 |
| _version_ | 1797615076521279488 |
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| author | Zhixin Xie Tianlong Wu Jing Mu Ping Zhang Xuan Wang Tao Liang Yihan Weng Jianfang Luo Huimin Yu |
| author_facet | Zhixin Xie Tianlong Wu Jing Mu Ping Zhang Xuan Wang Tao Liang Yihan Weng Jianfang Luo Huimin Yu |
| author_sort | Zhixin Xie |
| collection | DOAJ |
| description | Objectives: Our study aimed to demonstrate the influence of left ventricular (LV) diastolic dysfunction on the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR). Methods: One hundred vessels from 90 patients were retrospectively analyzed. All patients underwent echocardiography, coronary computed tomography angiography (CCTA), CT-FFR, invasive coronary angiography (ICA), and fractional flow reserve (FFR). The study population was divided into normal and dysfunction groups according to the LV diastolic function, and the diagnostic performance in both groups was assessed. Results: There was a good correlation between CT-FFR and FFR (R = 0.768 <i>p</i> < 0.001) on a per-vessel basis. The sensitivity, specificity, and accuracy were 82.3%, 81.8%, and 82%, respectively. The sensitivity, specificity, and accuracy were 84.6%, 88.5%, and 87.2% in the normal group and 81%, 77.5%, and 78.7% in the dysfunction group, respectively. CT-FFR showed no statistically significant difference in the AUC in the normal group vs. the dysfunction group (AUC: 0.920 [95% CI 0.787–0.983] vs. 0.871 [95% CI 0.761–0.943], Z = 0.772 <i>p</i> = 0.440). However, there was still a good correlation between CT-FFR and FFR in the normal group (R = 0.767, <i>p</i> < 0.001) and dysfunction group (R = 0.767 <i>p</i> < 0.001). Conclusions: LV diastolic dysfunction had no effect on the diagnostic accuracy of CT-FFR. CT-FFR has good diagnostic performance in both LV diastolic dysfunction and the normal group and can be used as an effective tool for finding lesion-specific ischemia while screening for arterial disease in patients. |
| first_indexed | 2024-03-11T07:21:22Z |
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| language | English |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-329deb6d0a494cd6afa2d989a736ea052023-11-17T07:57:29ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125172410.3390/jcm12051724Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow ReserveZhixin Xie0Tianlong Wu1Jing Mu2Ping Zhang3Xuan Wang4Tao Liang5Yihan Weng6Jianfang Luo7Huimin Yu8The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaThe Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Cardiology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaObjectives: Our study aimed to demonstrate the influence of left ventricular (LV) diastolic dysfunction on the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve (CT-FFR). Methods: One hundred vessels from 90 patients were retrospectively analyzed. All patients underwent echocardiography, coronary computed tomography angiography (CCTA), CT-FFR, invasive coronary angiography (ICA), and fractional flow reserve (FFR). The study population was divided into normal and dysfunction groups according to the LV diastolic function, and the diagnostic performance in both groups was assessed. Results: There was a good correlation between CT-FFR and FFR (R = 0.768 <i>p</i> < 0.001) on a per-vessel basis. The sensitivity, specificity, and accuracy were 82.3%, 81.8%, and 82%, respectively. The sensitivity, specificity, and accuracy were 84.6%, 88.5%, and 87.2% in the normal group and 81%, 77.5%, and 78.7% in the dysfunction group, respectively. CT-FFR showed no statistically significant difference in the AUC in the normal group vs. the dysfunction group (AUC: 0.920 [95% CI 0.787–0.983] vs. 0.871 [95% CI 0.761–0.943], Z = 0.772 <i>p</i> = 0.440). However, there was still a good correlation between CT-FFR and FFR in the normal group (R = 0.767, <i>p</i> < 0.001) and dysfunction group (R = 0.767 <i>p</i> < 0.001). Conclusions: LV diastolic dysfunction had no effect on the diagnostic accuracy of CT-FFR. CT-FFR has good diagnostic performance in both LV diastolic dysfunction and the normal group and can be used as an effective tool for finding lesion-specific ischemia while screening for arterial disease in patients.https://www.mdpi.com/2077-0383/12/5/1724fractional flow reservecoronary computed tomography angiography-derived fractional flow reserveleft ventricular diastolic dysfunction |
| spellingShingle | Zhixin Xie Tianlong Wu Jing Mu Ping Zhang Xuan Wang Tao Liang Yihan Weng Jianfang Luo Huimin Yu Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve Journal of Clinical Medicine fractional flow reserve coronary computed tomography angiography-derived fractional flow reserve left ventricular diastolic dysfunction |
| title | Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve |
| title_full | Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve |
| title_fullStr | Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve |
| title_full_unstemmed | Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve |
| title_short | Influence of Left Ventricular Diastolic Dysfunction on the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve |
| title_sort | influence of left ventricular diastolic dysfunction on the diagnostic performance of coronary computed tomography angiography derived fractional flow reserve |
| topic | fractional flow reserve coronary computed tomography angiography-derived fractional flow reserve left ventricular diastolic dysfunction |
| url | https://www.mdpi.com/2077-0383/12/5/1724 |
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