Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient
Background: Carcinoma Cervix is one of the common malignant pathology causing considerable morbidity and mortality in women. One of the important aspects of management of carcinoma cervix is its early detection and appropriate management since delay in the diagnosis can have catastrophic consequence...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-04-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/41268 |
| _version_ | 1818756211516899328 |
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| author | Supriya Lokhande Neethika Raghuwanshi Madhuri Dhakne Sushma Deshmukh |
| author_facet | Supriya Lokhande Neethika Raghuwanshi Madhuri Dhakne Sushma Deshmukh |
| author_sort | Supriya Lokhande |
| collection | DOAJ |
| description | Background: Carcinoma Cervix is one of the common malignant pathology causing considerable morbidity and mortality in women. One of the important aspects of management of carcinoma cervix is its early detection and appropriate management since delay in the diagnosis can have catastrophic consequences. Unfortunately in developing countries in many cases, diagnosis is delayed due to non-availability of facilities at rural areas. To overcome this screening methods such as Visual Inspection with Acetic Acid (VIA) and PAP smear can be done in high-risk patients and in selected cases cervical biopsy can be done.
Aims and Objectives: (1) To compare VIA and PAP smear in relation to colposcopy as a screening method for premalignant lesions of cervix. (2) To study the efficacy of VIA as a primary screening test for detection of premalignant lesions of cervical cancer.
Materials and Methods: This was a prospective analytical study in which 100 women with unhealthy cervix attending obstetrics and gynecology out patient department who were willing to participate and gave written informed consent were enrolled in the study on the basis of a predefined inclusion and exclusion criteria. VIA was done. Pap smear was taken and slides were stained with modified Papanicolaou staining method and examined under light microscope. we compared the efficacy of VIA and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient, and the results were confirmed with the help of colposcopy examination and its histopathological correlation with guided biopsy.
Results: Mean age of the study population was found to be 40.94 years. When VIA, PAP Smear, and colposcopy were compared highest sensitivity was seen in VIA whereas colposcopy showed highest accuracy (82%). PAP was found to have a higher specificity (84.62%) as compared to VIA or colposcopy. Highest positive predictive value and negative predictive value was seen in PAP smear (78.95%) and colposcopy (86.96%).
Conclusion: VIA is an easy to perform and highly sensitive test for diagnosis of carcinoma cervix however it has got a poor specificity. Colposcopy was found to be a better diagnostic test as it was both more sensitive as well as specific to diagnose premalignant lesions. |
| first_indexed | 2024-12-18T05:51:26Z |
| format | Article |
| id | doaj.art-329ea5ce67de4c208d77b4c607f7cd14 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-18T05:51:26Z |
| publishDate | 2022-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-329ea5ce67de4c208d77b4c607f7cd142022-12-21T21:18:54ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-04-0113498105https://doi.org/10.3126/ajms.v13i4.41268Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patientSupriya Lokhande 0Neethika Raghuwanshi 1https://orcid.org/0000-0002-0290-6848Madhuri Dhakne 2https://orcid.org/0000-0001-9011-3882Sushma Deshmukh 3Speciality Medical Officer, Department of Obstetrics and Gynaecology, HBT Trauma Care Hospital, Mumbai, Maharashtra, IndiaAssociate Professor, Department of Obstetrics and Gynaecology, Government Medical College, Akola, Maharashtra, India Associate Professor, Department of Obstetrics and Gynaecology, Government Medical College, Akola, Maharashtra, India Associate Professor, Department of Obstetrics and Gynaecology, Government Medical College, Akola, Maharashtra, IndiaBackground: Carcinoma Cervix is one of the common malignant pathology causing considerable morbidity and mortality in women. One of the important aspects of management of carcinoma cervix is its early detection and appropriate management since delay in the diagnosis can have catastrophic consequences. Unfortunately in developing countries in many cases, diagnosis is delayed due to non-availability of facilities at rural areas. To overcome this screening methods such as Visual Inspection with Acetic Acid (VIA) and PAP smear can be done in high-risk patients and in selected cases cervical biopsy can be done. Aims and Objectives: (1) To compare VIA and PAP smear in relation to colposcopy as a screening method for premalignant lesions of cervix. (2) To study the efficacy of VIA as a primary screening test for detection of premalignant lesions of cervical cancer. Materials and Methods: This was a prospective analytical study in which 100 women with unhealthy cervix attending obstetrics and gynecology out patient department who were willing to participate and gave written informed consent were enrolled in the study on the basis of a predefined inclusion and exclusion criteria. VIA was done. Pap smear was taken and slides were stained with modified Papanicolaou staining method and examined under light microscope. we compared the efficacy of VIA and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient, and the results were confirmed with the help of colposcopy examination and its histopathological correlation with guided biopsy. Results: Mean age of the study population was found to be 40.94 years. When VIA, PAP Smear, and colposcopy were compared highest sensitivity was seen in VIA whereas colposcopy showed highest accuracy (82%). PAP was found to have a higher specificity (84.62%) as compared to VIA or colposcopy. Highest positive predictive value and negative predictive value was seen in PAP smear (78.95%) and colposcopy (86.96%). Conclusion: VIA is an easy to perform and highly sensitive test for diagnosis of carcinoma cervix however it has got a poor specificity. Colposcopy was found to be a better diagnostic test as it was both more sensitive as well as specific to diagnose premalignant lesions.https://www.nepjol.info/index.php/AJMS/article/view/41268carcinoma cervixcolposcopypap smearvia |
| spellingShingle | Supriya Lokhande Neethika Raghuwanshi Madhuri Dhakne Sushma Deshmukh Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient Asian Journal of Medical Sciences carcinoma cervix colposcopy pap smear via |
| title | Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient |
| title_full | Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient |
| title_fullStr | Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient |
| title_full_unstemmed | Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient |
| title_short | Efficacy of Visual inspection with acetic acid (VIA) and PAP smear as a screening method for diagnosis of premalignant lesions of cervix in high-risk patient |
| title_sort | efficacy of visual inspection with acetic acid via and pap smear as a screening method for diagnosis of premalignant lesions of cervix in high risk patient |
| topic | carcinoma cervix colposcopy pap smear via |
| url | https://www.nepjol.info/index.php/AJMS/article/view/41268 |
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