Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis
Viral infections cause many severe human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/11/1125 |
| _version_ | 1827675712699498496 |
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| author | Everton M. da Silva Hérika D. A. Vidal Arlene G. Corrêa |
| author_facet | Everton M. da Silva Hérika D. A. Vidal Arlene G. Corrêa |
| author_sort | Everton M. da Silva |
| collection | DOAJ |
| description | Viral infections cause many severe human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods. |
| first_indexed | 2024-03-10T05:09:45Z |
| format | Article |
| id | doaj.art-329eb120dc67468ea2c2713f848ed14d |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:09:45Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-329eb120dc67468ea2c2713f848ed14d2023-11-23T00:55:37ZengMDPI AGPharmaceuticals1424-82472021-11-011411112510.3390/ph14111125Advances on Greener Asymmetric Synthesis of Antiviral Drugs via OrganocatalysisEverton M. da Silva0Hérika D. A. Vidal1Arlene G. Corrêa2Centre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, SP, BrazilCentre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, SP, BrazilCentre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, SP, BrazilViral infections cause many severe human diseases, being responsible for remarkably high mortality rates. In this sense, both the academy and the pharmaceutical industry are continuously searching for new compounds with antiviral activity, and in addition, face the challenge of developing greener and more efficient methods to synthesize these compounds. This becomes even more important with drugs possessing stereogenic centers as highly enantioselective processes are required. In this minireview, the advances achieved to improve synthetic routes efficiency and sustainability of important commercially antiviral chiral drugs are discussed, highlighting the use of organocatalytic methods.https://www.mdpi.com/1424-8247/14/11/1125antiviralsgreen chemistryselectivityasymmetric synthesisorganocatalysis |
| spellingShingle | Everton M. da Silva Hérika D. A. Vidal Arlene G. Corrêa Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis Pharmaceuticals antivirals green chemistry selectivity asymmetric synthesis organocatalysis |
| title | Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis |
| title_full | Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis |
| title_fullStr | Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis |
| title_full_unstemmed | Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis |
| title_short | Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis |
| title_sort | advances on greener asymmetric synthesis of antiviral drugs via organocatalysis |
| topic | antivirals green chemistry selectivity asymmetric synthesis organocatalysis |
| url | https://www.mdpi.com/1424-8247/14/11/1125 |
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