Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening

Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening

Matrix metalloproteinases (MMPs) are the family of proteases that are mainly responsible for degrading extracellular matrix (ECM) components. In the skin, the overexpression of MMPs as a result of ultraviolet radiation triggers an imbalance in the ECM turnover in a process called photoaging, which u...

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Bibliographic Details
Main Authors: Aleix Gimeno, Doretta Cuffaro, Elisa Nuti, María José Ojeda-Montes, Raúl Beltrán-Debón, Miquel Mulero, Armando Rossello, Gerard Pujadas, Santiago Garcia-Vallvé
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
photoaging
skin treatment
non-selective matrix metalloproteinases
natural products
bioactivity prediction
in vitro validation
Online Access:https://www.mdpi.com/1420-3049/26/15/4553

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