Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia

Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia

Abstract Background Perioperative neurocognitive disorders (PNDs) are common complications observed among surgical patients. Accumulating evidence suggests that neuroinflammation is one of the major contributors to the development of PNDs, but the underlying mechanisms remain unclear. Methods qPCR a...

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Bibliographic Details
Main Authors: Xuwu Xiang, Xiaodong Tang, Yang Yu, Shulan Xie, Lu Liu, ManLi Chen, Rong Zhang, Xianhui Kang, Yueying Zheng, Guang Yang, Shuyuan Gan, Shengmei Zhu
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
Cognitive decline
Surgery
Lipocalin-2
Neuroinflammation
Microglia
Online Access:https://doi.org/10.1186/s12974-022-02455-5

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