Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells
Water contamination due to the presence of lead is one of the leading causes of environmental and health hazards because of poor soil and groundwater waste management. Herein we report the synthesis of functionally modified luminescent carbon quantum dots (CQDs) obtained from watermelon juice as pot...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Journal of Imaging |
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| Online Access: | https://www.mdpi.com/2313-433X/9/1/19 |
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| author | Kundan Singh Rawat Vikram Singh Chandra Prakash Sharma Akanksha Vyas Priyanka Pandey Jagriti Singh Neeraj Mohan Gupta Monika Sachdev Atul Goel |
| author_facet | Kundan Singh Rawat Vikram Singh Chandra Prakash Sharma Akanksha Vyas Priyanka Pandey Jagriti Singh Neeraj Mohan Gupta Monika Sachdev Atul Goel |
| author_sort | Kundan Singh Rawat |
| collection | DOAJ |
| description | Water contamination due to the presence of lead is one of the leading causes of environmental and health hazards because of poor soil and groundwater waste management. Herein we report the synthesis of functionally modified luminescent carbon quantum dots (CQDs) obtained from watermelon juice as potential nanomaterials for the detection of toxic Pb<sup>2+</sup> ions in polluted water and cancer cells. By introducing surface passivating ligands such as ethanolamine (EA) and ethylenediamine (ED) in watermelon juice, watermelon-ethanolamine (WMEA)-CQDs and watermelon-ethylenediamine (WMED)-CQDs exhibited a remarkable ~10-fold and ~6-fold increase in fluorescence intensity with respect to non-doped WM-CQDs. The relative fluorescence quantum yields of WMEA-CQDs and WMED-CQDs were found to be 8% and 7%, respectively, in an aqueous medium. Among various functionally-modified CQDs, only WMED-CQDs showed high selectivity towards Pb<sup>2+</sup> ions with a remarkably good limit of detection (LoD) of 190 pM, which is less than that of the permissible limit (72 nM) in drinking water. The functionally altered WMED-CQDs detected Pb<sup>2+</sup> metal ions in polluted water and in a human cervical cancer cell line (HeLa), thus advocating new vistas for eco-friendly nanomaterials for their use as diagnostic tools in the environment and biomedical research areas. |
| first_indexed | 2024-03-09T12:07:27Z |
| format | Article |
| id | doaj.art-32a4bc1606b94d68bb37baeecf5d250c |
| institution | Directory Open Access Journal |
| issn | 2313-433X |
| language | English |
| last_indexed | 2024-03-09T12:07:27Z |
| publishDate | 2023-01-01 |
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| record_format | Article |
| series | Journal of Imaging |
| spelling | doaj.art-32a4bc1606b94d68bb37baeecf5d250c2023-11-30T22:55:34ZengMDPI AGJournal of Imaging2313-433X2023-01-01911910.3390/jimaging9010019Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer CellsKundan Singh Rawat0Vikram Singh1Chandra Prakash Sharma2Akanksha Vyas3Priyanka Pandey4Jagriti Singh5Neeraj Mohan Gupta6Monika Sachdev7Atul Goel8Fluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaFluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaFluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, IndiaFluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaFluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaFluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, IndiaFluorescent Chemistry Lab, Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaWater contamination due to the presence of lead is one of the leading causes of environmental and health hazards because of poor soil and groundwater waste management. Herein we report the synthesis of functionally modified luminescent carbon quantum dots (CQDs) obtained from watermelon juice as potential nanomaterials for the detection of toxic Pb<sup>2+</sup> ions in polluted water and cancer cells. By introducing surface passivating ligands such as ethanolamine (EA) and ethylenediamine (ED) in watermelon juice, watermelon-ethanolamine (WMEA)-CQDs and watermelon-ethylenediamine (WMED)-CQDs exhibited a remarkable ~10-fold and ~6-fold increase in fluorescence intensity with respect to non-doped WM-CQDs. The relative fluorescence quantum yields of WMEA-CQDs and WMED-CQDs were found to be 8% and 7%, respectively, in an aqueous medium. Among various functionally-modified CQDs, only WMED-CQDs showed high selectivity towards Pb<sup>2+</sup> ions with a remarkably good limit of detection (LoD) of 190 pM, which is less than that of the permissible limit (72 nM) in drinking water. The functionally altered WMED-CQDs detected Pb<sup>2+</sup> metal ions in polluted water and in a human cervical cancer cell line (HeLa), thus advocating new vistas for eco-friendly nanomaterials for their use as diagnostic tools in the environment and biomedical research areas.https://www.mdpi.com/2313-433X/9/1/19carbon quantum dotswatermelon juicegreen synthesislead ion sensingbioimaging |
| spellingShingle | Kundan Singh Rawat Vikram Singh Chandra Prakash Sharma Akanksha Vyas Priyanka Pandey Jagriti Singh Neeraj Mohan Gupta Monika Sachdev Atul Goel Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells Journal of Imaging carbon quantum dots watermelon juice green synthesis lead ion sensing bioimaging |
| title | Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells |
| title_full | Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells |
| title_fullStr | Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells |
| title_full_unstemmed | Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells |
| title_short | Picomolar Detection of Lead Ions (Pb<sup>2+</sup>) by Functionally Modified Fluorescent Carbon Quantum Dots from Watermelon Juice and Their Imaging in Cancer Cells |
| title_sort | picomolar detection of lead ions pb sup 2 sup by functionally modified fluorescent carbon quantum dots from watermelon juice and their imaging in cancer cells |
| topic | carbon quantum dots watermelon juice green synthesis lead ion sensing bioimaging |
| url | https://www.mdpi.com/2313-433X/9/1/19 |
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