Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs
<p>Abstract</p> <p>Background</p> <p>Porcine reproductive and respiratory syndrome virus (PRRSV) and <it>Streptococcus suis </it>are common pathogens in pigs. In samples collected during the porcine high fever syndrome (PHFS) outbreak in many parts of China,...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-08-01
|
| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/7/1/184 |
| _version_ | 1818347198715265024 |
|---|---|
| author | Xu Min Wang Shujie Li Linxi Lei Liancheng Liu Yonggang Shi Wenda Wu Jiabin Li Liqin Rong Fulong Xu Mingming Sun Guangli Xiang Hua Cai Xuehui |
| author_facet | Xu Min Wang Shujie Li Linxi Lei Liancheng Liu Yonggang Shi Wenda Wu Jiabin Li Liqin Rong Fulong Xu Mingming Sun Guangli Xiang Hua Cai Xuehui |
| author_sort | Xu Min |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Porcine reproductive and respiratory syndrome virus (PRRSV) and <it>Streptococcus suis </it>are common pathogens in pigs. In samples collected during the porcine high fever syndrome (PHFS) outbreak in many parts of China, PRRSV and <it>S. suis </it>serotype 7 (SS7) have always been isolated together. To determine whether PRRSV-SS7 coinfection was the cause of the PHFS outbreak, we evaluated the pathogenicity of PRRSV and/or SS7 in a pig model of single and mixed infection.</p> <p>Results</p> <p>Respiratory disease, diarrhea, and anorexia were observed in all infected pigs. Signs of central nervous system (CNS) disease were observed in the highly pathogenic PRRSV (HP-PRRSV)-infected pigs (4/12) and the coinfected pigs (8/10); however, the symptoms of the coinfected pigs were clearly more severe than those of the HP-PRRSV-infected pigs. The mortality rate was significantly higher in the coinfected pigs (8/10) than in the HP-PRRSV- (2/12) and SS7-infected pigs (0/10). The deceased pigs of the coinfected group had symptoms typical of PHFS, such as high fever, anorexia, and red coloration of the ears and the body. The isolation rates of HP-PRRSV and SS7 were higher and the lesion severity was greater in the coinfected pigs than in monoinfected pigs.</p> <p>Conclusion</p> <p>HP-PRRSV infection increased susceptibility to SS7 infection, and coinfection of HP-PRRSV with SS7 significantly increased the pathogenicity of SS7 to pigs.</p> |
| first_indexed | 2024-12-13T17:30:21Z |
| format | Article |
| id | doaj.art-32a5d78cb8e8484097b4b6faf4bd8261 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-13T17:30:21Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-32a5d78cb8e8484097b4b6faf4bd82612022-12-21T23:37:04ZengBMCVirology Journal1743-422X2010-08-017118410.1186/1743-422X-7-184Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigsXu MinWang ShujieLi LinxiLei LianchengLiu YonggangShi WendaWu JiabinLi LiqinRong FulongXu MingmingSun GuangliXiang HuaCai Xuehui<p>Abstract</p> <p>Background</p> <p>Porcine reproductive and respiratory syndrome virus (PRRSV) and <it>Streptococcus suis </it>are common pathogens in pigs. In samples collected during the porcine high fever syndrome (PHFS) outbreak in many parts of China, PRRSV and <it>S. suis </it>serotype 7 (SS7) have always been isolated together. To determine whether PRRSV-SS7 coinfection was the cause of the PHFS outbreak, we evaluated the pathogenicity of PRRSV and/or SS7 in a pig model of single and mixed infection.</p> <p>Results</p> <p>Respiratory disease, diarrhea, and anorexia were observed in all infected pigs. Signs of central nervous system (CNS) disease were observed in the highly pathogenic PRRSV (HP-PRRSV)-infected pigs (4/12) and the coinfected pigs (8/10); however, the symptoms of the coinfected pigs were clearly more severe than those of the HP-PRRSV-infected pigs. The mortality rate was significantly higher in the coinfected pigs (8/10) than in the HP-PRRSV- (2/12) and SS7-infected pigs (0/10). The deceased pigs of the coinfected group had symptoms typical of PHFS, such as high fever, anorexia, and red coloration of the ears and the body. The isolation rates of HP-PRRSV and SS7 were higher and the lesion severity was greater in the coinfected pigs than in monoinfected pigs.</p> <p>Conclusion</p> <p>HP-PRRSV infection increased susceptibility to SS7 infection, and coinfection of HP-PRRSV with SS7 significantly increased the pathogenicity of SS7 to pigs.</p>http://www.virologyj.com/content/7/1/184 |
| spellingShingle | Xu Min Wang Shujie Li Linxi Lei Liancheng Liu Yonggang Shi Wenda Wu Jiabin Li Liqin Rong Fulong Xu Mingming Sun Guangli Xiang Hua Cai Xuehui Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs Virology Journal |
| title | Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs |
| title_full | Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs |
| title_fullStr | Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs |
| title_full_unstemmed | Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs |
| title_short | Secondary infection with <it>Streptococcus suis </it>serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs |
| title_sort | secondary infection with it streptococcus suis it serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs |
| url | http://www.virologyj.com/content/7/1/184 |
| work_keys_str_mv | AT xumin secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT wangshujie secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT lilinxi secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT leiliancheng secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT liuyonggang secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT shiwenda secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT wujiabin secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT liliqin secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT rongfulong secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT xumingming secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT sunguangli secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT xianghua secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs AT caixuehui secondaryinfectionwithitstreptococcussuisitserotype7increasesthevirulenceofhighlypathogenicporcinereproductiveandrespiratorysyndromevirusinpigs |