The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination.

The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination.

Activation-induced deaminase (AID) initiates somatic hypermutation, gene conversion and class switch recombination by deaminating variable and switch region DNA cytidines to uridines. AID is predominantly cytoplasmic and must enter the nuclear compartment to initiate these distinct antibody gene div...

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Bibliographic Details
Main Authors: Zachary L Demorest, Donna A MacDuff, William L Brown, Scott G Morham, Leslie V Parise, Reuben S Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2907397?pdf=render

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