Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease
Abstract Apolipoprotein C3 (apoC3) and apolipoprotein A5 (apoA5), encoded by APOA1/C3/A4/A5 gene cluster, are two critical regulators of plasma triglyceride (TG) metabolism. Deficiency of apoC3 or apoA5 led to significant decreased or increased plasma TG levels, respectively. Recent studies indicate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-019-1166-5 |
| _version_ | 1818664265294282752 |
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| author | Wen Dai Ziyu Zhang Chun Yao Shuiping Zhao |
| author_facet | Wen Dai Ziyu Zhang Chun Yao Shuiping Zhao |
| author_sort | Wen Dai |
| collection | DOAJ |
| description | Abstract Apolipoprotein C3 (apoC3) and apolipoprotein A5 (apoA5), encoded by APOA1/C3/A4/A5 gene cluster, are two critical regulators of plasma triglyceride (TG) metabolism. Deficiency of apoC3 or apoA5 led to significant decreased or increased plasma TG levels, respectively. Recent studies indicated apoC3 and apoA5 also played roles in plasma remnant cholesterol, high density lipoprotein (HDL) and hepatic TG metabolisms. Moreover, large scale population genetic studies indicated that loss of function mutations in APOC3 and APOA5 gene conferred decreased and increased risk of coronary artery disease (CAD), respectively. This manuscript mainly reviewed existing evidences suggesting the opposite role of apoC3 and apoA5 in lipid metabolism and CAD risk, and discussed the potential correlation between these two apolipoproteins. |
| first_indexed | 2024-12-17T05:29:59Z |
| format | Article |
| id | doaj.art-32a6c372f77a4ff885eedbd5222d7789 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-17T05:29:59Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-32a6c372f77a4ff885eedbd5222d77892022-12-21T22:01:45ZengBMCLipids in Health and Disease1476-511X2019-12-011811710.1186/s12944-019-1166-5Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery diseaseWen Dai0Ziyu Zhang1Chun Yao2Shuiping Zhao3Department of Cardiology, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiology, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiology, The Second Xiangya Hospital, Central South UniversityDepartment of Cardiology, The Second Xiangya Hospital, Central South UniversityAbstract Apolipoprotein C3 (apoC3) and apolipoprotein A5 (apoA5), encoded by APOA1/C3/A4/A5 gene cluster, are two critical regulators of plasma triglyceride (TG) metabolism. Deficiency of apoC3 or apoA5 led to significant decreased or increased plasma TG levels, respectively. Recent studies indicated apoC3 and apoA5 also played roles in plasma remnant cholesterol, high density lipoprotein (HDL) and hepatic TG metabolisms. Moreover, large scale population genetic studies indicated that loss of function mutations in APOC3 and APOA5 gene conferred decreased and increased risk of coronary artery disease (CAD), respectively. This manuscript mainly reviewed existing evidences suggesting the opposite role of apoC3 and apoA5 in lipid metabolism and CAD risk, and discussed the potential correlation between these two apolipoproteins.https://doi.org/10.1186/s12944-019-1166-5Apolipoprotein C3Apolipoprotein A5Coronary artery diseaseAtherosclerosisRemnant cholesterol |
| spellingShingle | Wen Dai Ziyu Zhang Chun Yao Shuiping Zhao Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease Lipids in Health and Disease Apolipoprotein C3 Apolipoprotein A5 Coronary artery disease Atherosclerosis Remnant cholesterol |
| title | Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease |
| title_full | Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease |
| title_fullStr | Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease |
| title_full_unstemmed | Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease |
| title_short | Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease |
| title_sort | emerging evidences for the opposite role of apolipoprotein c3 and apolipoprotein a5 in lipid metabolism and coronary artery disease |
| topic | Apolipoprotein C3 Apolipoprotein A5 Coronary artery disease Atherosclerosis Remnant cholesterol |
| url | https://doi.org/10.1186/s12944-019-1166-5 |
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