Nucleophosmin 1 expression in acute myeloid leukemia
Nucleophosmin1 is a multifunctional protein that shuttles between nucleus and cytoplasm in some subtypes of acute myeloid leukemias. Mutated Nucleophosmin1 expresses aberrantly in the cytoplasm of the cell and transports from nucleolus to the cytoplasm. It is diagnosed by immunohistochemical techniq...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-10-01
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| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | https://rcm.mums.ac.ir/article_4715_8db911e93acca41805966048e19c91ab.pdf |
| _version_ | 1797976062147166208 |
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| author | Mohammad Davoudi Parvaneh Davoodi |
| author_facet | Mohammad Davoudi Parvaneh Davoodi |
| author_sort | Mohammad Davoudi |
| collection | DOAJ |
| description | Nucleophosmin1 is a multifunctional protein that shuttles between nucleus and cytoplasm in some subtypes of acute myeloid leukemias. Mutated Nucleophosmin1 expresses aberrantly in the cytoplasm of the cell and transports from nucleolus to the cytoplasm. It is diagnosed by immunohistochemical techniques, flow cytometry assay and mutational analysis.The aim of this study is to evaluate the effects of Nucleophosmin1 mutation on the clinical presentations, prognosis, diagnosis and the treatment of acute myeloid leukemia. Thirteen articles were extracted from PubMed, Google scholar and Scopus in which the Nucleophosmin1 mutation correlated with gingival hyperplasia, high white blood cell count, lymphadenopathy, high platelet count and other signs and symptoms of myelomonocytic and monocytic acute myeloid leukemias. This mutation is a provisional entity in the classification of acute myeloid leukemia, which influences on the prognosis, clinical course and the treatment of some subtypes of acute myeloid leukemias. Nucleophosmin1 mutation has favorable prognostic value in the absence of other concomitant mutations. |
| first_indexed | 2024-04-11T04:45:21Z |
| format | Article |
| id | doaj.art-32aa1f2167fe41a2994fe8630d120583 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-11T04:45:21Z |
| publishDate | 2015-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-32aa1f2167fe41a2994fe8630d1205832022-12-27T13:12:38ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922015-10-012420921110.17463/RCM.2015.04.0114715Nucleophosmin 1 expression in acute myeloid leukemiaMohammad Davoudi0Parvaneh Davoodi1Faculty of Dentistry, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Department of Pathology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Nucleophosmin1 is a multifunctional protein that shuttles between nucleus and cytoplasm in some subtypes of acute myeloid leukemias. Mutated Nucleophosmin1 expresses aberrantly in the cytoplasm of the cell and transports from nucleolus to the cytoplasm. It is diagnosed by immunohistochemical techniques, flow cytometry assay and mutational analysis.The aim of this study is to evaluate the effects of Nucleophosmin1 mutation on the clinical presentations, prognosis, diagnosis and the treatment of acute myeloid leukemia. Thirteen articles were extracted from PubMed, Google scholar and Scopus in which the Nucleophosmin1 mutation correlated with gingival hyperplasia, high white blood cell count, lymphadenopathy, high platelet count and other signs and symptoms of myelomonocytic and monocytic acute myeloid leukemias. This mutation is a provisional entity in the classification of acute myeloid leukemia, which influences on the prognosis, clinical course and the treatment of some subtypes of acute myeloid leukemias. Nucleophosmin1 mutation has favorable prognostic value in the absence of other concomitant mutations.https://rcm.mums.ac.ir/article_4715_8db911e93acca41805966048e19c91ab.pdfacute myeloid leukemiaimmunohistochemistarynpm1 mutation |
| spellingShingle | Mohammad Davoudi Parvaneh Davoodi Nucleophosmin 1 expression in acute myeloid leukemia Reviews in Clinical Medicine acute myeloid leukemia immunohistochemistary npm1 mutation |
| title | Nucleophosmin 1 expression in acute myeloid leukemia |
| title_full | Nucleophosmin 1 expression in acute myeloid leukemia |
| title_fullStr | Nucleophosmin 1 expression in acute myeloid leukemia |
| title_full_unstemmed | Nucleophosmin 1 expression in acute myeloid leukemia |
| title_short | Nucleophosmin 1 expression in acute myeloid leukemia |
| title_sort | nucleophosmin 1 expression in acute myeloid leukemia |
| topic | acute myeloid leukemia immunohistochemistary npm1 mutation |
| url | https://rcm.mums.ac.ir/article_4715_8db911e93acca41805966048e19c91ab.pdf |
| work_keys_str_mv | AT mohammaddavoudi nucleophosmin1expressioninacutemyeloidleukemia AT parvanehdavoodi nucleophosmin1expressioninacutemyeloidleukemia |