Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination

Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination

Naturally acquired immunity (NAI) to Plasmodium falciparum malaria is mainly mediated by IgG antibodies but the subclasses, epitope targets and effector functions have not been unequivocally defined. Dissecting the type and specificity of antibody responses mediating NAI is a key step toward develop...

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Bibliographic Details
Main Authors: Carlota Dobaño, Rebeca Santano, Marta Vidal, Alfons Jiménez, Chenjerai Jairoce, Itziar Ubillos, David Dosoo, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, Aintzane Ayestaran, Clarissa Valim, Kwaku Poku Asante, Seth Owusu-Agyei, David Lanar, Virander Chauhan, Chetan Chitnis, Sheetij Dutta, Evelina Angov, Benoit Gamain, Ross L. Coppel, James G. Beeson, Linda Reiling, Deepak Gaur, David Cavanagh, Ben Gyan, Augusto J. Nhabomba, Joseph J. Campo, Gemma Moncunill
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
Malaria
Plasmodium falciparum
antibody
IgG subclass
naturally acquired immunity
protection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00439/full

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