Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study
Introduction: Hypertension or high blood pressure is one of the main reasons of fatality in the world. The role of vitamin D in developing hypertension has not been proved yet. Some studies have shown positive correlation between low serum vitamin D level and hypertension. Due to this fact, reco...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10187/25522_CE[Ra]_F(Sh)_PF1(PrG_SS)_PFA(PrG_SS).pdf |
| Summary: | Introduction: Hypertension or high blood pressure is one of
the main reasons of fatality in the world. The role of vitamin
D in developing hypertension has not been proved yet. Some
studies have shown positive correlation between low serum
vitamin D level and hypertension. Due to this fact, recognising
hypertension risk factors such as potential impact of low serum
vitamin D level seems to be required.
Aim: This study was conducted to evaluate potential impact of
serum vitamin D level on hypertension.
Materials and Methods: This case-control study had 188
subjects including 55 cases suffering from hypertension and
133 controls with normal blood pressure in Hamadan, Iran. After
taking the medical history and physical examination, 5 cc of their
blood was taken to measure their serum 25-Hydroxyvitamin D
[25(OH)D] level through ELISA test. Data analysis was done by
version 16.0 of SPSS software and used independent sample
t-test and Chi-square test for related comparisons.
Results: Mean and standard deviation of serum 25(OH)D level
in patients suffering from hypertension was 13.10±9.7 ng/ml
and in control group was 20.87±10.34 ng/ml. This variance was
statistically significant (p<0.001). Mean serum 25(OH)D level
in both case and control groups was measured after gender
and age stratification. Mean serum 25(OH)D level in cases
and controls was 13.12±11.4 ng/ml and 21.38±11.47 ng/ml in
males (p=0.016) and 13.10±9.91 ng/ml and 19.19±10.55 ng/ml
(p=0.004) in females, respectively. Mean serum 25(OH)D level in
under 50-year-old was 10.82±8.73 ng/ml and 20.07±11.17 ng/
ml in cases and controls respectively (p<0.001). In over 50-yearold, there was no significant relationship between mean serum
25(OH)D and blood pressure levels (p>0.05).
Conclusion: According to this study, reverse relationship
between serum 25(OH)D and blood pressure levels was seen. |
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| ISSN: | 2249-782X 0973-709X |