Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study
Introduction: Hypertension or high blood pressure is one of the main reasons of fatality in the world. The role of vitamin D in developing hypertension has not been proved yet. Some studies have shown positive correlation between low serum vitamin D level and hypertension. Due to this fact, reco...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10187/25522_CE[Ra]_F(Sh)_PF1(PrG_SS)_PFA(PrG_SS).pdf |
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| author | Behshad Naghshtabrizi Shiva Borzouei Pedram Bigvand Mohamad Ali Seifrabiei |
| author_facet | Behshad Naghshtabrizi Shiva Borzouei Pedram Bigvand Mohamad Ali Seifrabiei |
| author_sort | Behshad Naghshtabrizi |
| collection | DOAJ |
| description | Introduction: Hypertension or high blood pressure is one of
the main reasons of fatality in the world. The role of vitamin
D in developing hypertension has not been proved yet. Some
studies have shown positive correlation between low serum
vitamin D level and hypertension. Due to this fact, recognising
hypertension risk factors such as potential impact of low serum
vitamin D level seems to be required.
Aim: This study was conducted to evaluate potential impact of
serum vitamin D level on hypertension.
Materials and Methods: This case-control study had 188
subjects including 55 cases suffering from hypertension and
133 controls with normal blood pressure in Hamadan, Iran. After
taking the medical history and physical examination, 5 cc of their
blood was taken to measure their serum 25-Hydroxyvitamin D
[25(OH)D] level through ELISA test. Data analysis was done by
version 16.0 of SPSS software and used independent sample
t-test and Chi-square test for related comparisons.
Results: Mean and standard deviation of serum 25(OH)D level
in patients suffering from hypertension was 13.10±9.7 ng/ml
and in control group was 20.87±10.34 ng/ml. This variance was
statistically significant (p<0.001). Mean serum 25(OH)D level
in both case and control groups was measured after gender
and age stratification. Mean serum 25(OH)D level in cases
and controls was 13.12±11.4 ng/ml and 21.38±11.47 ng/ml in
males (p=0.016) and 13.10±9.91 ng/ml and 19.19±10.55 ng/ml
(p=0.004) in females, respectively. Mean serum 25(OH)D level in
under 50-year-old was 10.82±8.73 ng/ml and 20.07±11.17 ng/
ml in cases and controls respectively (p<0.001). In over 50-yearold, there was no significant relationship between mean serum
25(OH)D and blood pressure levels (p>0.05).
Conclusion: According to this study, reverse relationship
between serum 25(OH)D and blood pressure levels was seen. |
| first_indexed | 2024-12-11T05:05:30Z |
| format | Article |
| id | doaj.art-32aa9b7050c54b7d84eaed115cb8249b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T05:05:30Z |
| publishDate | 2017-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-32aa9b7050c54b7d84eaed115cb8249b2022-12-22T01:20:02ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-07-01117LC01LC0310.7860/JCDR/2017/25522.10187Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control StudyBehshad Naghshtabrizi0Shiva Borzouei1Pedram Bigvand2Mohamad Ali Seifrabiei3Associate Professor, Department of Cardiology, Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.Assistant Professor, Department of Internal Medicine, Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.Junior Resident, Department of Internal Medicine, Babol Medical School, Babol University of Medical Sciences, Babol, Mazandaran, Iran.Associate Professor, Department of Community Medicine, Hamadan Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.Introduction: Hypertension or high blood pressure is one of the main reasons of fatality in the world. The role of vitamin D in developing hypertension has not been proved yet. Some studies have shown positive correlation between low serum vitamin D level and hypertension. Due to this fact, recognising hypertension risk factors such as potential impact of low serum vitamin D level seems to be required. Aim: This study was conducted to evaluate potential impact of serum vitamin D level on hypertension. Materials and Methods: This case-control study had 188 subjects including 55 cases suffering from hypertension and 133 controls with normal blood pressure in Hamadan, Iran. After taking the medical history and physical examination, 5 cc of their blood was taken to measure their serum 25-Hydroxyvitamin D [25(OH)D] level through ELISA test. Data analysis was done by version 16.0 of SPSS software and used independent sample t-test and Chi-square test for related comparisons. Results: Mean and standard deviation of serum 25(OH)D level in patients suffering from hypertension was 13.10±9.7 ng/ml and in control group was 20.87±10.34 ng/ml. This variance was statistically significant (p<0.001). Mean serum 25(OH)D level in both case and control groups was measured after gender and age stratification. Mean serum 25(OH)D level in cases and controls was 13.12±11.4 ng/ml and 21.38±11.47 ng/ml in males (p=0.016) and 13.10±9.91 ng/ml and 19.19±10.55 ng/ml (p=0.004) in females, respectively. Mean serum 25(OH)D level in under 50-year-old was 10.82±8.73 ng/ml and 20.07±11.17 ng/ ml in cases and controls respectively (p<0.001). In over 50-yearold, there was no significant relationship between mean serum 25(OH)D and blood pressure levels (p>0.05). Conclusion: According to this study, reverse relationship between serum 25(OH)D and blood pressure levels was seen.https://jcdr.net/articles/PDF/10187/25522_CE[Ra]_F(Sh)_PF1(PrG_SS)_PFA(PrG_SS).pdfhigh blood pressurerisk factorvitamin deficiency |
| spellingShingle | Behshad Naghshtabrizi Shiva Borzouei Pedram Bigvand Mohamad Ali Seifrabiei Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study Journal of Clinical and Diagnostic Research high blood pressure risk factor vitamin deficiency |
| title | Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study |
| title_full | Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study |
| title_fullStr | Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study |
| title_full_unstemmed | Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study |
| title_short | Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study |
| title_sort | evaluation of the relationship between serum 25 hydroxy vitamin d and hypertension in hamadan iran a case control study |
| topic | high blood pressure risk factor vitamin deficiency |
| url | https://jcdr.net/articles/PDF/10187/25522_CE[Ra]_F(Sh)_PF1(PrG_SS)_PFA(PrG_SS).pdf |
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